The Company has two distinct Investigational New Drug Applications related to NBI-98854, tardive
dyskinesia and Tourette syndrome, open with the Division of Psychiatry Products at the FDA.
The symptoms of tardive
blepharospasm may fluctuate.
SNC-102 has the potential to be the first FDA-approved drug for tardive
dyskinesia, a debilitating and often irreversible movement disorder, said William Kerns, DVM, Chief Executive Officer of Synchroneuron Inc.
Extract of Ginkgo biloba treatment for tardive
dyskinesia in schizophrenia: a randomized, double-blind, placebo-controlled trial.
Despite the many studies showing that Reglan was associated with tardive
The FDA's statement refers to an unspecified number of spontaneous reports of tardive
dyskinesia in patients who took metoclopramide, the majority of whom took it for more than 3 months, Metoclopramide was approved in 1983 for treating symptomatic gastroesophageal reflux and for diabetic gastroparesis.
The atypical or second-generation antipsychotic agents (SGAs) are often drugs of choice in the treatment of psychotic illness, based on evidence of their reduced risk for associated acute extrapyramidal side-effects and tardive
dyskinesia, compared with the first-generation antipsychotics (FGAs).
The impact ranges from unpleasant in mild cases of tardive
dyskinesia to "hugely life altering" in people who develop tardive
dystonia on the older drugs.
A major side effect of long-term use of typicals is tardive
In long-term studies, the prevalence of tardive
dyskinesia often exceeds 50% of all treated patients.
Other issues addressed include emotional symptoms seen with dystonia, autoimmune-mediated movement disorders, tardive
dyskinesia, and the treatment and diagnosis and treatment of psychogenic movement disorders.
Although about 50 vineyards may claim Grand Cru status, the only other idiosyncrasies to look out for on labels are "Vendage Tardive
or Selection des Grands Nobles" indicating that the grapes are late picked (Tardive
), or contain noble rot (Grands Nobles), which does not always guarantee a sweet wine.