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tandem mass spectrometry

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tandem mass spectrometry (MS/MS),
a two-step technique used to analyze a sample for a predetermined set of substances, either by using a separate mass spectroscope for each step or by using the same spectroscope to perform the steps sequentially. In the first stage, a predetermined set of ions is selected for fragmentation. In the second, mass spectra are produced for the fragments. This technique is used in screening newborns for multiple metabolic disorders from a single blood sample.


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Tandem mass spectrometry, a type of technology used to screen newborns for rare health disorders, provides a better outcome for patients at 6 years of age, with fewer deaths and fewer significant disabilities, according to a study of the practice in Australia.
Development and validation of a gas chromatography-negative chemical ionization tandem mass spectrometry method for the determination of ethyl glucuronide in hair and its application to forensic toxicology.
The development of faster and cheaper technologies such as tandem mass spectrometry and microchip arrays, however, enable programs to screen for far greater numbers of disorders, including many for which no readily effective treatments presently exist.
 
 
 
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