tacrolimus


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tacrolimus

 [tak″ro-li´mus]
an immunosuppressant derived from a species of Streptomyces, having actions similar to those of cyclosporine; administered orally or intravenously to prevent rejection of organ transplants and topically to treat moderate to severe atopic dermatitis.

tacrolimus

/tac·ro·li·mus/ (tak″ro-li´mus) a macrolide immunosuppressant having actions similar to those of cyclosporine; used to prevent rejection of organ transplants; also used topically to treat moderate to severe atopic dermatitis.

tacrolimus

(tə-krō′lə-məs)
n.
An immunosuppressive drug produced by the actinomycete Streptomyces tsukubaensis, C44H69NO12, used in combination with corticosteroids to prevent rejection of organ transplants.

tacrolimus

an immunosuppressive drug that modifies biological response.
indications This drug is prescribed to suppress the immune system after transplantation of the liver or other organs and can be applied topically for the treatment of dermatitis unresponsive to other medications.
contraindications This drug should not be given to patients with allergy to tacrolimus or those receiving potassium-sparing diuretics, cycloSPORINE, or other immunosuppressive agents, with the exception of adrenal corticosteroids.
adverse effects The side effects most often reported include tremor, headache, diarrhea, hypertension, nausea, renal dysfunction, hyperglycemia, and increased risk of infection.

tacrolimus

FK506, Prograf Immunology An immunosuppressant that inhibits IL-2 synthesis and binding; it is similar to, and synergistic with, cyclosporine, up to 50-fold more immunosuppressive than cyclosporine; it is used in BM, kidney, liver, lung, and other transplants Adverse effects Neurotoxicity–tremor, seizures, white matter disease, headache, nausea, paresthesias of hands, feet, insomnia; nephrotoxicity, hyperglycemia, hirsutism, paresthesia, ↑ lipids, ↑ K+, HUS, ↓ Mg2+. Cf Cyclosporine.

tacrolimus

A potent immunosuppressant macrolide compound isolated from a bacterium. Tacrolimus is effective in reducing the risk of rejection of solid-organ transplants especially liver transplants. It has been successfully used as a monotherapy to prevent graft rejections and has virtually eliminated immunosuppression-related morbidity. It has also been found useful in ointment form for the treatment of moderate-to-severe atopic dermatitis in which it has been found as effective as strong topic steroids. Brand names are Prograf and Protopic.

immunosuppressants

Drugs that prevent or reduce the immune response. They are used in the treatment of a variety of severe inflammations such as uveitis, scleritis, keratoconjunctivitis sicca, Behçet's syndrome, sympathetic ophthalmia, and to prevent corneal graft rejection. They include the corticosteroids (e.g. prednisolone), ciclosporin (cyclosporine), tacrolimus, and cytotoxic agents (e.g. azathioprine, chlorambucil, cyclophosphamide, methotrexate). It must be noted that immunosuppressants render the patient more susceptible to infection because immunity is reduced.

tacrolimus (FK506),

n brand name: Prograf;
drug class: immunosuppressant;
action: inhibits T-lymphocyte activation leading to immunosuppression;
use: prophylaxis of organ rejection in patients receiving allogenic liver transplants.

tacrolimus

an immunosuppressive agent derived from Streptomyces tsukabaensis. It selectively binds FK-binding proteins and the complex inhibits calcineurin.
References in periodicals archive ?
branded as Envarsus XR (tacrolimus extended-release tablets) for prophylaxis of organ rejection in kidney transplant patients converted from tacrolimus immediate release formulations in combination with other immunosuppressants.
As the number of organ transplants and the number of cases of immune disease increase, the sales value of tacrolimus in China is expected to keep growing.
The present case was considered severely active because of the ferritin and IL-18 levels and was thought to be refractory; therefore, we decided to prescribe tacrolimus in combination with GC, including two courses of mPSL pulse therapy and MTX.
Patients indicated they applied topical tacrolimus a median of two times per week.
Low hematocrit values also have been reported to give false-positive tacrolimus concentrations using the MEIA assay (13).
9) Avrupa tacrolimus ve siklosporin mikroemulsiyon bobrek nakli calisma grubunun 560 hastalik serisinde ise ilk 6 ayda biyopsi ile kanitlanmis akut rejeksiyon oranlariCsA da %37.
We experienced a case of severe PBS/IC that was completely cured by combination therapy of prednisolone and tacrolimus.
The survival advantage afforded patients treated with tacrolimus rather than cyclosporine post-OLT was similar to the difference between high and low preoperative MELD score in the cyclosporine-treated patients (P = 0.
Fourteen women remain on long-term tacrolimus ointment.
LIM-0705 is designed to chaperone tacrolimus away from vulnerable organs and back into the bloodstream.
175mg/kg/day) plus basiliximab (without maintenance corticosteroids) and MMF was associated with lower tacrolimus exposure, and significantly reduced renal function impairment and acute rejection incidence compared to prolonged-release tacrolimus administered at maximum recommended dose (0.
Tacrolimus (FK506, 804 Da) is a macrolide lactone isolated from the fermentation product of the bacteria Steptomyces tsukubaensis (17).