t-plasminogen activator


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t-plasminogen activator

 [plaz-min´o-jen ak´tĭ-va″tor]
see tissue plasminogen activator.

t-plasminogen activator

/t-plas·min·o·gen ac·ti·va·tor/ (plaz-min´o-jen″ ak´tĭ-va-ter) see under activator.

PLAT

A gene on chromosome 8p12 that encodes tissue plasminogen activator, which converts inactive plasminogen to plasmin by hydrolysing a single Arg-Val bond in plasminogen, thereby playing a key role in tissue remodelling, degradation, cell migration and other cellular events. PLAT directly facilitates neuronal migration.