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t-PA

   Also found in: Dictionary/thesaurus, Acronyms, Encyclopedia, Wikipedia 0.01 sec.
TPA (t-PA)
2. total parenteral alimentation (see parenteral nutrition); t-plasminogen activator.

t-PA
tissue plasminogen activator.

t-PA
Activase®, Alteplase®, tissue-plasminogen activator Cardiology A thrombolytic that upregulates fibrinolysis, activating conversion of plasminogen to plasmin, an enzyme that degrades fibrin clots, fibrinogen, and other clotting factors, ergo reperfusing Pts with acutely occluded coronary arteries; SK has a half-life of 6-8 minutes, an expected 60-80% rate of reperfusion, is nonallergenic and nonantigenic, evokes little hypotension, and is theoretically, more clot specific. See Thrombolytic therapy. Cf APSAC, Streptokinase.


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Sustained fibrinolysis after administration of t-PA despite its short half life in the circulation.
However, the new multi-center study found the risk of intracranial hemorrhage after t-PA treatment does not outweigh the clear benefits of the drug for most patients.
TNK-tPA is a selectively mutated version of natural t-PA.
 
 
 
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