systemic

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systemic

 [sis-tem´ik]
pertaining to or affecting the body as a whole.
systemic disease one affecting a number of tissues that perform a common function.

sys·tem·ic

(sis-tem'ik),
Relating to a system; specifically somatic, relating to the entire organism as distinguished from any of its individual parts.

systemic

/sys·tem·ic/ (sis-tem´ik) pertaining to or affecting the body as a whole.

systemic

[sistem′ik]
Etymology: Gk, systema
pertaining to the whole body rather than to a localized area or regional part of the body.

sys·tem·ic

(sis-tem'ik)
Relating to a system; specifically somatic, relating to the entire organism as distinguished from any of its individual parts.

systemic

1. Pertaining to something that affects the whole body rather than one part of it.
2. Of the blood circulation supplying all parts of the body except the lungs.
3. Of a drug taken by mouth or given by injection, as distinct from a drug applied externally.

systemic

distributed throughout the whole of an organism.

Systemic

A term used to describe a medicine that has effects throughout the body, as opposed to topical drugs that work on the skin. Most medicines that are taken by mouth or by injection are systemic drugs.

systemic

(1) relating to a system as a whole, e.g. with reference to pathological conditions, affecting the whole body, as opposed to being localized; (2) with reference to the circulation of the blood, the route from the left side of the heart through the vessels supplying the whole body except the lungs, and returning to the right side of the heart.

systemic

body-wide effects of a specific disease, or a drug (Table 1)
Table 1: Long-term systemic medication in the perioperative period
Systemic drugEffects of sudden withdrawal of long-term medication
CorticosteroidLong-term corticosteroid therapy (including high-dose inhaled corticosteroid) leads to adrenal atrophy
Patients will show a precipitous fall in blood pressure if systemic corticosteroids are suddenly withdrawn
Patients may require an increased dose of systemic steroid during the perioperative period
Antiepileptic
Antiparkinsonian drugs
Antipsychotics
Anxiolytics
Bronchodilators
Cardiovascular drugs
Glaucoma drugs
Immunosuppressants
Thyroid supplements
The sudden withdrawal of these drugs will lead to breakthrough of the underlying disease state.
Thus their use should be continued during the perioperative period
Anticoagulants (aspirin, warfarin)Anticoagulant therapy is usually maintained during the perioperative period, using low-molecular-weight heparin, e.g. Fragmin). Surgery is preceded by 4 days without warfarin, with 48 hours of subcuticular heparin immediately before surgery. The warfarin regimen is usually restarted on the day of, or the day after, surgery, whilst continuing to use heparin. Heparin therapy is usually discontinued 4-7 days after surgery and the patient maintained on warfarin therapy with early post-operative INR monitoring
Combined oral contraceptives
Hormone replacement therapy
As these drugs predispose to venous thrombosis, they are usually stopped for the perioperative period
AntidepressantsThese drugs are gradually withdrawn in the presurgery period (to avoid withdrawal symptoms) and resumed postsurgically, as necessary
Monoamine oxidase inhibitors (MAOIs)In order to avoid potential drug interactions with medications that may be used in the perioperative period, MAOIs should be withdrawn 2 weeks before surgery
Tricyclic antidepressantsThese are usually maintained during the perioperative period, but patients may show arrhythmias or hypotension
Lithium carbonateThis should be stopped 24 hours before major surgery
It may be continued throughout minor surgery, but fluids and electrolytes should be monitored
Potassium-sparing diureticsWithheld on the day of surgery (patients may develop hyperkalaemia if renal perfusion becomes impaired or tissue is damaged during surgery)

systemic

pertaining to or affecting the body as a whole.

systemic inflammatory response (SIR)
a specific condition recognized in critical care medicine, characterized by febrile response, increased heart and respiratory rates, and leukocytosis.
systemic lupus erythematosus
systemic neuroaxial dystrophy
systemic therapy
treatment with a drug that is absorbed into the bloodstream and distributed to all parts of the body except where there is a specific barrier.

Patient discussion about systemic

Q. Is fibromyalgia related to Central Nervous System? Is fibromyalgia related to Central Nervous System? Among men and women who is more prone to the symptoms of fibromyalgia?

A. here is a quote from the National Fibromyalgia Association site:

"Little research has been conducted that measures the prevalence of fibromyalgia, and estimates vary widely as to the proportion of male versus female patients. A 1999 epidemiology study conducted in London found a female to male ratio of roughly three to one. However, a 2001 review of the research literature in Current Rheumatology Reports stated the ratio was nine to one."

Q. on what systems does ADHD effects?

A. Central nervous system. Which usually affects the hormonal state and any other system there is...

Q. on what system in the body does a Fibromyalgia effects?

A. Fibromyalgia effects the musculoskeletal and neuronal systems mainly. It is known to cause general weakness and unexplained fatigue, and a syndrome of pain, associated with different locations in the body. People suffer from chronic and extreme tenderness to light touch. Other symptoms include muscle aches, tingling and muscle spasms.

More discussions about systemic
References in periodicals archive ?
Banks classified as systemically important will be required to hold additional capital in the range of 0.
On the latter aspect, it is important to note that the consultation does not concern regulatory measures applicable to daily operations, but rather the introduction of "extraordinary" measures that may be needed to contain the fallout from the failure of systemically important non-bank financial institutions.
There is an extensive literature on what makes a financial firm systemically important and the difficulty of resolving such firms when they become insolvent.
I suspect the systemically important designated banks, if they are few in number, will see a flow of business to them," he said.
The bank's CEO, Josef Ackermann, said that a move to create a list of banks that are systemically important would only distract regulators from their actual job of regulating the banking system as a whole.
In the comment letter, the ACLI, representing the entire life industry, voiced alarm about the FSOC's desire to determine if insurers are systemically risky and therefore subject to federal oversight based on subjective scrutiny of their books by federal examiners--not on hard and fast rules that insurers will be able to challenge in court.
Among other things, the legislation strengthens consolidated supervision of systemically important financial institutions and gives the government tools to wind down failing financial firms, Bernanke said in a July 15 statement.
The company said that QPI-1002 is the first synthetic siRNA administered systemically to humans for the prophylaxis of acute kidney injury and delayed graft function.
While the Federal Reserve Board is "well suited" to the task of being the consolidated supervisor for systemically important nonbanks, a system for resolving large, troubled nonbanks such as insurers "analogous to the regime currently used by the Federal Deposit Insurance Corporation" is also needed, he said.
Major topics of this presentation include GAO's reporting on the Troubled Asset Relief Program (TARP), the Capital Purchase Program (CPP), the Automotive Industry Financing Program, the Home Affordable Mortgage Modification Program (HAMP), Systemically Significant Failing Institutions Program (SSFI), and measuring the performance of TARP.
This formulation is expected to enable the drug to be equally distributed throughout the body systemically.
Once this process is completed, all systemically important banks operating in New Zealand will be locally incorporated.