systemic mast cell disease

systemic mast cell disease

a heterogeneous group of diseases with four major divisions: indolent mastocystosis, the most common, which involves skin (for example, urticaria pigmentosa), marrow, and the gastrointestinal tract; mastocytosis with an associated hematologic disorder (that is, mast cell infiltrates in marrow, spleen, liver, and lymph nodes); mast cell leukemia (that is, immature mast cells infiltrating marrow, peripheral blood, and extramedullary tissues); and aggressive mastocytosis (that is, accumulation of mast cells in various organs, release of mast cell mediators producing a clinical sign).
References in periodicals archive ?
A bone marrow biopsy demonstrated systemic mast cell disease involving 5 to 10% of a hypercellular bone marrow and a diagnosis of systemic mastocytosis was made.
Clinical, genetic, and therapeutic insights into systemic mast cell disease.
Flt-3 and c-kit mutation studies in a spectrum of chronic myeloid disorders including systemic mast cell disease.
Full browser ?