systemic lupus erythematosus (LE) e. (SLE)

lupus erythematosus (LE)

the Latin word lupus means wolf and erythematosus refers to redness; abbreviated LE. The name lupus erythematosus has been used since the 13th century because human medicine physicians thought the shape and color of the skin lesions (butterfly rash) gave affected patients a wolf-like appearance. Currently, there are at least two recognized autoimmune disorders: discoid lupus erythematosus and systemic lupus erythematosus.

lupus erythematosus (LE) e. cell

a mature neutrophilic polymorphonuclear leukocyte, which has phagocytized a spherical, homogeneous-appearing inclusion, itself derived from nuclear material of degenerating leukocytes and coated with antinuclear antibody; a characterisitic of lupus erythematosus, but also found in analogous connective tissue disorders or immune-mediated disorders.

lupus erythematosus (LE) e. cell test

see lupus erythematosus phenomenon (below).

cutaneous lupus erythematosus (LE) e

see discoid lupus erythematosus (below).

discoid lupus erythematosus (LE) e. (DLE)

an autoimmune skin disease of dogs, characterized by depigmentation, erythema, scaling, erosions, ulcerations and crusting, particularly on and spreading up the bridge of the nose, and sometimes the face and lips. Immunoglobulins and/or complement are deposited at the basement membrane zone in the skin. The disease is exacerbated by exposure to ultraviolet light (sunlight). The disorder called 'collie nose' or solar dermatitis has in the past included many cases of dogs with DLE.

lupus erythematosus (LE) e. phenomenon, LE test

the formation of LE cells on incubation of the clotted blood or bone marrow of affected animals at 98.6°F (37°C). The clot is disrupted and centrifuged, the white cells are smeared on a glass slide and examined for LE cells.

systemic lupus erythematosus (LE) e. (SLE)

a multisystem, autoimmune disease of dogs and cats. An extremely wide variety of clinical signs may occur, but immune-mediated polyarthritis, hemolytic anemia and skin disease are most common.

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