systemic inflammatory response syndrome


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Related to systemic inflammatory response syndrome: septic shock

systemic inflammatory response syndrome

clinical state consisting of two or more coexisting conditions: fever or hypothermia, tachycardia, tachypnea, and an abnormally high leukocyte count.

systemic inflammatory response syndrome

clinical state consisting of two or more coexisting conditions: fever or hypothermia, tachycardia, tachypnea, and an abnormally high leukocyte count.

systemic inflammatory response syndrome

A term that 'was developed to imply a clinical response arising from a nonspecific insult and includes two or more of the following. See Sepsis, Septic shock, Severe sepsis.
Systemic inflammatory responses
Temperature < 36ºC or > 38ºC
Heart rate > 90 beats/min
Respiratory rate pCO2 < 32 mm Hg or > 20 breaths/min
WBC count < 4 x 109 or > 12 x 109 or , or the presence of > 0.10 immature neutrophils

systemic inflammatory response syndrome

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SIRS

Any severe illness characterized by a heart rate > 90 beats per min, respirations exceeding 20 breaths per minute, a PaCO2 of less than 32 mm Hg, and a white blood count greater than 12,000 cells/mL or less than 4000 cells/mL (or the presence of more than 10 percent immature (band) white blood cells. SIRS can begin with any serious illness or injury involving inflammation but is most often associated with systemic infection (sepsis) caused by gram-negative bacteria. See: sepsis; septic shock

Etiology

Lipopolysaccharide endotoxins released by gram-negative and gram-positive bacteria bind with lymphocytes and endothelial cells, stimulating a cascade of cytokine release, which produces systemic inflammation of blood vessels, tissues, and organs. Shock develops when cytokines cause vasodilation and increased vascular permeability; SIRS is one of the main causes of multiple organ dysfunction syndrome.

Treatment

Treatment for SIRS is focused on treating the primary cause. Multiple antibiotic therapy is required in sepsis. Supportive measures include the use of intravenous fluids and pressors, to support blood pressure, and intensive monitoring and optimization of oxygenation, ventilation, blood pressure, cardiac rhythms, serum electrolytes, and renal function.

References in periodicals archive ?
Clinical laboratory differentiation of infectious versus non-infectious systemic inflammatory response syndrome.
Selenium in Intensive Care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock.
As has been previously reported, one death occurred in a patient receiving ocrelizumab 2 x 1000mg, at week 14, secondary to a complicated course of systemic inflammatory response syndrome.
DX-88 is specifically engineered to be a highly selective, potent inhibitor of human plasma kallikrein, a key regulatory enzyme that is thought to play a role in systemic inflammatory response syndrome (SIRS) and associated complications such as blood loss.
DX-88 is also in a Phase I/II trial for the prevention of blood loss and effects of systemic inflammatory response syndrome in patients undergoing coronary artery bypass graft surgery.
The researchers found that despite women having a trend toward a lower incidence of severe sepsis, systemic inflammatory response syndrome and multi-organ dysfunction syndrome, there was no difference in mortality.
Sepsis is a systemic inflammatory response syndrome that results in the failure of the circulation to provide blood and oxygen to vital organs of the body.

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