Increased permeability and loss of the barrier function are two core characteristics of endothelial cells during sepsis, which are mainly attributed to morphological changes of endothelial cells, such as unbonding and protuberance of cell membrane, abnormal arrangement and obscured boundaries of endothelium, all above cause endothelium falling off from basal membrane, further translocation of circulatory substract, subendothelial edema, and systemic capillary leak syndrome
, the latter results in plasma shifting from the blood vessel to interstitial spaces, decrease of central venous pressure and mean arterial pressure, and then hypoperfusion of organs, secondary systemic tissue injury and edema, and even MODS in severe cases.
Idiopathic hypoalbuminemia is different from systemic capillary leak syndrome (SCLS) which presents with recurrent acute episodes of vascular leakage manifesting as severe hypotension, hypoalbuminemia, hemoconcentration, and generalized edema.
Idiopathic systemic capillary leak syndrome in children.
Idiopathic systemic capillary leak syndrome (SCLS): case report and systematic review of cases reported in the last 16 years.
Systemic capillary leak syndrome associated with compartment syndrome.
Treatment of the systemic capillary leak syndrome with terbutaline and theophylline.
Systemic capillary leak syndrome presenting as recurrent shock.
Systemic capillary leak syndrome (SCLS) is a rare disorder characterized by recurrent spontaneous episodes of hypovolaemic shock due to marked plasma shifts from the intravascular to the extravascular space.
Key Words: systemic capillary leak syndrome, compartment syndrome, rhabdomyolysis, polycythaemia
The systemic capillary leak syndrome (SCLS) is characterized by spontaneous recurrent episodes of hypotension, haemoconcentration, generalized oedema, and in most cases, the presence of a paraprotein.
In a series of eight patients, Tahirkheli and greipp from the mayo Clinic showed treatment with theophylline and terbutaline caused episodes of the systemic capillary leak syndrome to completely abate in some patients and decreased the incidence and severity of episodes in others (5).
Systemic capillary leak syndrome and monoclonal IgG gammapathy: studies in a sixth patient and review of the literature.