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a common manifestation of tertiary syphilis, involving the thoracic aorta, where destruction of elastic tissue in the media results in dilation and aneurysm formation.
inflammation of the aorta occurring in tertiary syphilis. It is characterized by diffuse dilation with gray, wheal-like plaques containing calcium on the inside and scars and wrinkles on the outside of the aorta. The middle layer of the aortic wall is usually infiltrated with plasma cells and contains fragments of damaged elastic tissue and many newly formed blood vessels. There may be damage to the cardiac valves, narrowing of the mouths of the coronary arteries, and formation of thrombi. Cerebral embolism may result. Signs of syphilitic aortitis are substernal pain, dyspnea, bounding pulse, and high systolic blood pressure. Penicillin may slow the course of the disease, but it cannot reverse the structural damage to the vessels and the heart. Also called Döhle-Heller disease, luetic aortitis.
syphilitic aortitisInfectious disease The most common systemic change of late syphilis, most prominent in the ascending aorta and transverse arch; the vasa vasorum is obliterated, vasa media is necrosed and fibrotic. See Syphilis.
Döhle,(Doehle), Karl G.P., German histologist and pathologist, 1855-1928.
Döhle bodies - found in neutrophils of patients with infections, burns, trauma, pregnancy, or cancer. Synonym(s): Döhle inclusions; leukocyte inclusions
Döhle inclusions - Synonym(s): Döhle bodies
Döhle-Heller aortitis - a common manifestation of tertiary syphilis, involving the thoracic aorta, where destruction of elastic tissue in the media results in dilation and aneurysm formation. Synonym(s): syphilitic aortitis
syph·i·lit·ic a·or·ti·tis(sif'i-litik ā'ōr-tītis)
Common manifestation of tertiary syphilis, involving thoracic aorta, where destruction of elastic tissue in media results in dilation and aneurysm formation.