Furthermore, the accumulation of phosphorylated a-synuclein was observed in neuronal cell bodies in an AP-2 (a clathrin adaptor protein) subunit knockdown, mimicking synucleinopathy
([alpha]-synuclein-mediated neurodegenerative disorder).
Prion-like acceleration of a synucleinopathy
in a transgenic mouse model.
Evaluation of alpha-synuclein immunohistochemical methods for the detection of Lewy-type synucleinopathy
in gastrointestinal biopsies," Acta Neuropathologica Communications, vol.
Repurposingthe NRF2 activator dimethyl fumarate as therapy against synucleinopathy
in Parkinson's disease," Antioxidants & Redox Signaling, vol.
Also, considering this diagnosis would aid in diagnosing a synucleinopathy
disorder because a higher incidence of RBD was noted in patients who developed synucleinopathy
disorders (eg, Parkinson's disease [PD] and dementia with Lewy bodies [DLB]) compared with patients who developed nonsynucleinopathies (eg, frontotemporal dementia, corticobasal degeneration, progressive supranuclear palsy, mild cognitive impairment, primary progressive aphasia, and posterior cortical atrophy) or tauopathies (eg, Alzheimer's disease).
Boeve BF, Silber MH, Ferman TJ, Lucas JA, Parisi JE (2001) Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy.
2003) Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism.
The rule is very simple: RBD equals synucleinopathy, and it works almost every time," said Dr.
The findings "again underscore the selectivity of RBD for synucleinopathy.
In a poster titled "An inducible mouse model of synucleinopathy
," collaborators Dr.
A later extension of this hypothesis further posits that the synucleinopathy
may even first develop in the enteric nerves in the gut and later spread along the vagus nerve into the brain (Hawkes et al.
Depression in PD has been linked to dysfunctional dopaminergic neurotransmitters pathways as well as synucleinopathy
extending to other subcortical regions.