Normally, cardiolipin in mitochondria pulls synuclein
out of toxic protein deposits and refolds it into a non-toxic shape, the researchers added.
Familial parkinsonism with synuclein
pathology: clinical and PET studies of A30P mutation carriers.
Competent BL21 (DE3) Escherichia coli bacteria were transformed with a plasmid containing the ZF synuclein
gene, allowed to grow in 3 L Luria broth to 6.
BioArctic AB has entered into a strategically important collaboration with AbbVie (NYSE: ABBV), a global biopharmaceutical company, to develop and commercialize BioArctic's portfolio of antibodies directed against alpha- synuclein
for the treatment of Parkinson's disease and other potential indications.
The work is the first to link the release of alpha synuclein
, a naturally-occurring protein that plays a central role in the development of Parkinson's, with its most common genetic risk factor--GBA-1--shedding new light on its role in the progression of the devastating neurological condition and its symptoms.
All vaccines in this pool target alpha- Synuclein
, a protein that is key to the onset and the progression of both, Parkinson's and multiple system atrophy (MSA).
To assess the potential of EAS in this regard, we investigated its effect on the SH-SY5Y cells overexpressing wild-type [alpha]- synuclein
(WT-[alpha]-Syn) or A53T mutant [alpha]-synuclein
(A53T-[alpha]-Syn), and the implicated pathway it might mediate.
By normalizing brain levels of alpha synuclein
, beta amyloid and tau, it provides an avenue to treat Alzheimer's and Parkinson's disease early so as to prevent the onset or diminish the severity of cognitive decline.
PsychoGenics has obtained a license from the University of California, San Diego School of Medicine to two of their a- synuclein
transgenic mouse models, over-expressing human wild type a-synuclein
under control of the PDGF-promoter and the murine Thy-1 promoter.
Elevated alpha synuclein
mRNA levels are associated with craving in patients with alcoholism.
deposition and non-motor symptoms in Parkinson disease.
Parkinson's disease (PD), a neurodegenerative disorder, is characterized by the selective degeneration of the nigrostriatal dopaminergic neurons, continuing or permanent deficiency of dopamine, accretion of an abnormal form of alpha synuclein
in the adjacent neurons, and dysregulation of ubiquitin proteasomal system, mitochondrial metabolism, permeability and integrity, and cellular apoptosis resulting in rigidity, bradykinesia, resting tremor, and postural instability.