synovial cells


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syn·o·vi·al cells

fibroblastlike cells that form 1-6 epithelioid layers in the synovial membrane of joints; believed to contribute proteoglycans and hyaluronate to the synovial fluid.
References in periodicals archive ?
Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner.
Researchers from World Health Organization arthritis centers at the University of Alabama at Birmingham (UAB) and Mainz, West Germany, have found that, at least in the mouse model they are studying, the earliest change in tissues destined to become arthritic is not inflammation but an uncontrolled reproduction of synovial cells.
If the problem does prove to be proliferating synovial cells, "It could point the way to the development of agents to interrupt the process," says Koopman.
heteromalla, inhibits the cytokine secretion in LPS-stimulated human monocytic cells and synovial cells isolated from RA patients.
Our subsequent data defines the mechanism of action of chlorojanerin in inhibiting cytokine production in LPS-stimulated THP-1 cells, LPS-stimulated human monocytes as well as in clinically relevant synovial cells from a rheumatoid arthritis patient.
Similarly synovial cells from a RA patient were also challenged with a dose response of chlorojanerin to determine the effect on proinflammatory cytokines produced by these cells.
Effect of chlorojanerin on the production of TNF-[lapha] and IL-6 in LPS stimulated isolated human monocytes and synovial cells from RA patient
TNF-[alpha] release by the synovial cells was potently blocked ([IC.
This mitigation of TNF-a and IL-6 which was detected in a LPS stimulated cell line based screen and further reproduced in LPS stimulated primary human monocytes as well as in synovial cells from a rheumatoid patient highlights the potential of this compound as an anti-inflammatory agent.
We believe their discovery of this new cell surface marker on synovial cells will lead to exciting new developments in the treatment of rheumatoid arthritis.
The fibroblast-like synovial cell in rheumatoid arthritis: a key player in inflammation and joint destruction.