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synaptosome

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synaptosome /syn·ap·to·some/ (sin-ap´to-sōm″) any of the membrane-bound sacs that break away from axon terminals at a synapse after brain tissue has been homogenized in sugar solution; it contains synaptic vessels and mitochondria.
syn·ap·to·some (s-npt-sm)
n.
A saclike structure containing synaptic vesicles and mitochondria, which breaks away from axon terminals when brain tissue is homogenized under controlled conditions.

synaptosome
[sinap′təsōm′]
a presynaptic nerve terminal that has been separated from the rest of the neuron and isolated from homogenates of brain tissue. It appears as a membrane-bound structure containing synaptic vesicles.


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In addition, seeking the active principles, the in vitro effects of all purified compounds were compared on monoaminergic uptake assays using synaptosome preparations of different brain regions.
Reduced mitochondrial function was observed in in vivo synaptosome preparations, and although striatal dopamine levels were not decreased, there was an increased dopamine turnover and decreased motor activity.
Cloning of neuronal mtDNA variants in cultured cells by synaptosome fusion with mtDNA-less cells.
 
 
 
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