Our previous study showed that GluR5-containing kainate receptors (non-NMDA glutamate receptor) regulate the inhibitory synaptic transmission
through endogenous glutamate; therefore, we tested how neonatal propofol and etomidate exposure affect endogenous glutamatergic tonic regulation to inhibitory synaptic transmission
in P90 approximately rats.
26,27) Accordingly, the inhibition of mEPSCs suggested that the ketamine-induced inhibition of excitatory synaptic transmission
was resulted from the blockade of the postsynaptic glutamatergic receptors.
is primarily based on the regulated release of neurotransmitter from synaptic vesicles (Heine 2012).
This finding indicates that an increased contribution of NMDARs to synaptic transmission
may help to drive drinking under stressful/aversive conditions via actions in the limbic circuitry.
v][beta] forms part of VGCC complexes that underlie synaptic transmission
of sensory information and efferent events detected by cnidocytes to postsynaptic cells such as neurites and other cnidocytes, in a manner similar to that observed in other hydrozoans (Thurm et al.
Recombinant BDNF rescues deficits in basal synaptic transmission
and hippocampal LTP in BDNF knockout mice.
Thus the transmutation related free radical generation and altered calcium-magnesium ratios in the cell can alter synaptic transmission
, mitochondrial function, golgi body/ER function, lysosomal function, immune activation, cell proliferation, insulin resistance and cell death.
Adenosine is a neurotransmitter that normally inhibits synaptic transmission
and plasticity; that is, it induces sleepiness.
17) BDNF has emerged as a major regulator of synaptic transmission
and plasticity in the adult brain, with a TrKB distribution mainly at glutamatergic synapses.
Namely, AD was hypothesized to arise from a deficiency of cholinergic synaptic transmission
Lundbeck will focus on three main areas of biology: neurodegeneration, neuroinflammation and synaptic transmission
which are relevant to a wide range of brain disorders, including depression, schizophrenia, Parkinson's, Alzheimer's and Huntington's diseases.
The papers have been organized into sections that discuss the delineation of anatomical circuits for pain the dorsal horn; the regulators of fast synaptic transmission
in the dorsal horn; the regulators of slow synaptic transmission
in the dorsal horn; synaptic plasticity and the application of sensory information in the dorsal horn of the spinal cord; and mechanisms and targets fro chronic pain the dorsa horn, including arthritic pain, visceral pain, and neuropathic pain.