and Di Filippo, M, Dopamine-mediated regulation of corticostriatal synaptic plasticity
Although there are many types of synaptic plasticity
, this review is limited to homosynaptic plasticity that depends on postsynaptic voltage-gated calcium channels (VGCCs) and NMDA receptors (NMDARs).
Additional potential neuroprotective effects of curcumin and/or the curcuminoids include as an antidepressant; protection against aluminium induced neurotoxicity, ethanol-induced brain damage, sodium-arsenite toxicity, 3-nitorpropionic acid-induced toxicity, MPTP toxicity, traumatic brain injury, lead induced neurotoxicity, glutamate toxicity and brain focel ischemia; memory improvement by HIV glycoprotein; anti aging; reversal of amyloid pathology and ethanol induced neurotoxicity; and restoration of the synaptic plasticity
Writing in the journal Nature Medicine the US team, led by Dr Tony Wyss-Coray from Stanford University, said: "Our data indicate that exposure of aged mice to young blood late in life is capable of rejuvenating synaptic plasticity
and improving cognitive function.
Our findings suggest that green tea might increase the short-term synaptic plasticity
of the brain," said Prof.
One of the major functions of GluRs is the modulation of synaptic plasticity
, a property of the brain thought to be vital for memory and learning.
NMDA receptor subunit diversity: impact n receptor properties, synaptic plasticity
Neuronal calcium sensor proteins: emerging roles in membrane traffic and synaptic plasticity
Such stimulation of neuronal activity and normalisation of gene expression combined with the known effects of a5IA on synaptic plasticity
, might support the promnestic [memory enhancing] and therapeutic effects of the drug," he added.
It is important to recognize that the pathophysiology of dementing disorders like Alzheimer's disease is highly complex, with interactions between synaptic plasticity
, neuronal transmission and beta amyloid formation.
The NMDA receptor/ion channel complex: a drug target for modulating synaptic plasticity
They looked at the connections, or synapses, which control cognitive function, and the way they change in strength and properties - known as synaptic plasticity