Homologous carcinomas of the breasts, skin, and salivary glands: a histologic and immunohistochemical comparison of ductal mammary carcinoma, ductal sweat gland carcinoma, and salivary duct carcinoma.
The strong immunophenotypic overlap among breast cancers, salivary gland carcinomas, and sweat gland carcinomas of the skin with GCDFP-15 expression has been well documented.
It has also been described as malignant hidroacanthoma simplex, sweat gland carcinoma
, malignant intra-epidermal eccrine poroma, eccrine poro-epithelioma, dysplastic poroma, malignant syringoacanthoma and porocarcinoma.
Although vulvar sweat gland carcinoma is very rare, accounting for less than 1% of all malignant vulvar tumors, adenoid cystic carcinoma accounts for approximately 20% to 25% of all Bartholin gland malignancies.
Adenocarcinoma of the mammary-like glands of the vulva: a concept unifying sweat gland carcinoma of the vulva, carcinoma of supernumerary mammary glands and extramammary Paget's disease.
1] Biddlestone et al have described a young girl with progression of a histologically benign hidradenoma to a malignant sweat gland carcinoma
with metastasis over a period of 11 years.
Sweat gland carcinoma
of the hand (malignant acrospiroma).
Demographics of Cutaneous Metastatic Breast Carcinoma (CMBC) and Sweat Gland Carcinoma
(SGC) Cases Mean Age Case Group No.
It is generally accepted that the first case of a sweat gland carcinoma
was reported as early as 1865 by the renowned French pathologist Victor Andre Cornil.
16,31,32] Immunohistochemistry may provide useful information; in particular, diffuse positivity for CEA and negativity for gross cystic disease fluid protein 15 would favor the interpretation of primary sweat gland carcinoma
over one of metastatic breast cancer.
16) They found a statistically significant infrequency of gross cystic disease fluid protein-15 in eccrine sweat gland carcinomas
, a paucity of carcinoembryonic antigen in breast cancers, and an absence of estrogen receptor protein in salivary duct carcinomas.
Wick and coworkers (11) reported that gross cystic disease fluid protein 15 (BRST-2) was statistically significant in its lack of staining in eccrine sweat gland carcinomas
as compared to ductal carcinomas of the breast.