Syringomas are benign intraepidermal tumours of eccrine sweat ducts
mostly found in women at the time of adolescence.
We have just laid down some critical fundamentals of sweat gland and sweat duct
biology," Lu said.
Excisional biopsy revealed benign neoplastic changes of sweat duct
consisting of broad anastomosing bands in the deeper parts of epidermis extending to dermis.
Hence although formerly thought to be of mixed origin now syringoma is considered to be benign appendage tumour of intra- epidermal eccrine sweat duct
52] Myoepithelial cells have not been found in porocarcinomas, sclerosing sweat duct
carcinomas, extramammary Paget disease, malignant mixed tumors, or adenosquamous carcinomas,[51-53] whereas they have been occasionally detected in mucinous carcinomas, apocrine adenocarcinomas,[51,52] and adenoid cystic carcinomas.
Various theories postulate eccrine ductal blockage without damage to sweat ducts
,16 hyperkeratinization and obstruction of eccrine sweat duct
,17 blockage of neuroglandular transmission and inhibition of secretory mechanism at cellular level.
Elevated sweat chloride levels are a diagnostic hallmark that occur in CF patients and result directly from defective CFTR function in skin cells in the sweat duct
Syringoma, first described by Biesiadecki and Kaposi, is a benign appendageal tumour of intraepidermal eccrine sweat duct
Elevated sweat chloride levels are a diagnostic hallmark that occur in all CF patients and result directly from defective CFTR activity in epithelial cells in the sweat duct
It refers to depression of surface epidermis not related to opening of sweat duct
or pilosebaceous duct and is filled with keratin and pinkish exudates.
Sweat Chloride: Elevated sweat chloride levels are a diagnostic hallmark that occur in all CF patients and result directly from defective CFTR activity in epithelial cells in the sweat duct
Furthermore) single application of sunscreen is unlikely to clog sweat ducts