Production of the alkaloid swainsonine
by a fungal endosymbiont of
Cancer chemotherapy Cis-diamminedichloroplatinum (II) Golgi a-mannosidase 11 [alpha]-Mannosidase inhibitor Astragalus lentiginosus Cell cycle Swainsonine
Swainsonine is a natural [alpha]-mannosidase inhibitor found in numerous poisonous plants, such as Astragalus lentiginosus.
Effects of graded levels of bentonite on serum clinical profiles, metabolic hormones, and serum swainsonine
concentrations in lambs fed locoweed (Oxytropis sericea).
Ipomoea carnea is a toxic plant due to the alkaloids swainsonine and calystegines, which causes animal production economic losses in Northeast Argentina.
Identifieation of the glyeosidase inhibitors swainsonine and calystegine B2 in weir vine (Ipomoea sp.
The toxin, swainsonine, can weaken and eventually kill not only cattle, but also horses, sheep, goats, and other animals that graze on the dozen or so rangeland plants commonly known as locoweeds, says ARS chemist Russell J.
But medical researchers, feeding the compound to laboratory mice, have discovered that swainsonine also stops growth of malignant tumors.
In order to investigate the effects and mechanisms of swainsonine in C6 glioma cells, we carry out correlated experiments in vitro and in vivo.
Swainsonine is a potent and specific inhibitor of lysosomal acid and cytosolic [alpha]-mannosidases, as well as Golgi [alpha]-mannosidase II.
In Europe, swainsonine
has been studied widely for prevention of metastasis and cancer therapy.
Rooprai HK, Kandanearatchi A, Maidment SL, Christidou M, Trillo-Pazos G, Dexter DT, Rucklidge GJ, Widmer W, Pilkington GJ (2001) Evaluation of the effects of swainsonine
, captopril, tangeretin and nobiletin on the biological behavior of brain tumor cells in vitro.