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suppression test

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suppression test
A test or assay–eg, dexamethasone suppression test, used to determine whether a substance–hormone or protein being produced in excess is under the control of regulating or releasing factor(s), and therefore responsive to a feedback loop, or whether the excess production is autonomous, and not under feedback control. Cf Stimulation test.


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An overnight low-dose dexamethasone suppression test is more sensitive than the measurement of free cortisol levels.
Currently, diagnosis of a pseudo-Cushing state is normally based on negative tests for Cushing's, including a dexamethasone-CRH (corticotropin-releasing hormone) stimulation test, a loperamide suppression test, and/or a 1-mg overnight dexamethasone-suppression test, and/or resolution of hypercortisolism over the course of up to 18 months' follow-up.
 
 
 
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