superwarfarin

superwarfarin

Toxicology A warfarin–eg, brodifacoum, bromadiolone, difenacou, which is up to 100-fold more toxic, and has a T1/2 60 times longer than warfarin; ingestion causes severe and prolonged coagulopathy

superwarfarin

(soo″pĕr-wor′fă-rĭn)
Any of a group of anticoagulant drugs derived from warfarin, used principally for their toxic effect on vermin. Agents in this class have a long half life (weeks to months) compared with warfarin (half life about 1.5 days). They inhibit the synthesis of vitamin K-dependent clotting factors. The principal toxic effect is bleeding. Brodifacoum is a commonly used superwarfarin in the U.S.
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References in periodicals archive ?
Plasma superwarfarin levels and vitamin K| treatment in dogs with anticoagulant rodenticide poisoning.
The predominant rodenticide exposure is anticoagulant rodenticides, generally the superwarfarin type.
Ingestion of rat poisons containing superwarfarin (brodifacoum) is an important public health problem in the United States.
Superwarfarin poisoning was suspected and testing revealed a brodifacoum serum level of 0.
Superwarfarin poisoning was suspected, and testing revealed serum brodifacoum.
The ingestion of superwarfarin containing rodenticides, such as brodifacoum, may result in long lasting and potentially fatal coagulopathy.
Mosquito repellents and superwarfarin rodenticides are they really toxic in children?
Suspect superwarfarin poisoning in suicidal patients with coagulopathy, prolonged prothrombin time, and elevated INR that does not respond to large amounts of vitamin K.
Suspect superwarfarin poisoning in patients with coagulopathy, prologned prothrombin time, and elevated INR
Suspect superwarfarin poisoning in patients with prolonged prothrombin time and elevated international normalized ratio who do not respond to large amounts of vitamin K.
That is, until last week, when we had a potential poisoning with brodifacoum, one of the superwarfarin rodenticides.