sulphonylureas


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sul·fo·nyl·u·re·as

(sŭl'fō-nil-yūr'ē-ăz)
Derivatives of isopropylthiodiazylsulfanilamide, chemically related to the sulfonamides, which possess hypoglycemic action. Belonging to this series are acetohexamide, azepinamide, chlorpropamide, fluphenmepramide, glymidine, hydroxyhexamide, heptolamide, indylamide, thiohexamide, tolazamide, and tolbutamide.
Synonym(s): sulphonylureas.

sulphonylureas

A class of drugs used in the treatment of maturity onset (Type II), non-insulin dependency DIABETES. They are taken by mouth. Also known as oral hypoglycaemic drugs. Examples are glibenclamide (Daonil, Euglucon), gliclazide (Diamicron), glimepiride (Amaryl), glipizide (Glibenese, Minodiab), gliquidone (Glurenorm) and repaglinide (Novonorm).

sulphonylureas

oral hypoglycaemic agents (e.g. chlorpropamide, glibenclamide, gliclazide and tolbutamide); used to treat diabetes mellitus, in patients who retain some residual pancreatic function; stimulate pancreatic insulin secretion; may be used in conjunction with metformin, or acarbose, or glitazone, or isophane insulin; use associated with weight gain and hypoglycaemia; unsuitable for patients with reduced liver or renal function

sul·fo·nyl·u·re·as

(sŭl'fō-nil-yūr'ē-ăz)
Derivatives of isopropylthiodiazylsulfanilamide, chemically related to sulfonamides, whichpossess hypoglycemic action (e.g., acetohexamide, tolbutamide).
Synonym(s): sulphonylureas.
References in periodicals archive ?
Published in a leading diabetes journal produced by scientists from Cardi$ University, the study set out to compare the survival of diabetes patients prescribed with metformin with patients prescribed with another common diabetes drug called sulphonylurea.
As expected, a sulphonylurea agent, glipizide, stimulated the insulin secretion by around 194, 50 and 90% at 15, 30 and 60 min when compared to the hyperglycemic control group, respectively.
25 to 200 mg once daily, as well as all of the 62 patients randomized to receive treatment with 4 mg glimepiride (a sulphonylurea that acts as an insulin secretagogue) once daily, achieved significant least-squares mean reductions from baseline in hemoglobin Alc, compared with the 61 patients randomized to a placebo group.
0% of the patients were on either metformin or a sulphonylurea monotherapy respectively.
channel modulators like sulphonylureas, minoxidil, amiodarone, etc.
The sulphonylureas are another pancreatic stimulant class designed to stimulate the production of insulin.
2 Drugs used (N (%)) Metformin 32 (68%) 32 (63%) Sulphonylureas 18 (38%) 16 (31%) Insulin 37 (79%) 39 (76%) Aspirin 36 (77%) 32 (63%) Statin 18 (38%) 17 (33%) ACE inhibitors 36 (77%) 28 (71%) Age (mean [+ or -] SD) NS Years of education (mean [+ or -] SD) [HBAI.
Therefore, unlike the glucose-insensitive sulphonylureas, 19AJ agonists neither lowered normal fasting blood glucose nor caused hypoglycemia.
Biguanides and sulphonylureas were the two most frequently prescribed oral AHA therapy, 83.
The UKPDS showed that 53% of T2DM patients using only sulphonylureas required insulin after 6 years and 80% after 9 years.
London, Dec 4 (ANI): Sulphonylureas, a type of drug widely used to treat type 2 diabetes, has a greater risk of causing heart failure and death as compared to metformin, another popular antidiabetes drug, according to a study.
The study, funded by health charity Diabetes UK, shows that people with Type 2 diabetes and the gene variants who take diabetic drugs known as sulphonylureas may be less likely to develop diabetes complications such as heart disease, kidney disease and stroke.