sulphonylureas


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sul·fo·nyl·u·re·as

(sŭl'fō-nil-yūr'ē-ăz)
Derivatives of isopropylthiodiazylsulfanilamide, chemically related to the sulfonamides, which possess hypoglycemic action. Belonging to this series are acetohexamide, azepinamide, chlorpropamide, fluphenmepramide, glymidine, hydroxyhexamide, heptolamide, indylamide, thiohexamide, tolazamide, and tolbutamide.
Synonym(s): sulphonylureas.

sulphonylureas

A class of drugs used in the treatment of maturity onset (Type II), non-insulin dependency DIABETES. They are taken by mouth. Also known as oral hypoglycaemic drugs. Examples are glibenclamide (Daonil, Euglucon), gliclazide (Diamicron), glimepiride (Amaryl), glipizide (Glibenese, Minodiab), gliquidone (Glurenorm) and repaglinide (Novonorm).

sulphonylureas

oral hypoglycaemic agents (e.g. chlorpropamide, glibenclamide, gliclazide and tolbutamide); used to treat diabetes mellitus, in patients who retain some residual pancreatic function; stimulate pancreatic insulin secretion; may be used in conjunction with metformin, or acarbose, or glitazone, or isophane insulin; use associated with weight gain and hypoglycaemia; unsuitable for patients with reduced liver or renal function

sul·fo·nyl·u·re·as

(sŭl'fō-nil-yūr'ē-ăz)
Derivatives of isopropylthiodiazylsulfanilamide, chemically related to sulfonamides, whichpossess hypoglycemic action (e.g., acetohexamide, tolbutamide).
Synonym(s): sulphonylureas.
References in periodicals archive ?
Although most of the oral anti-diabetic drugs have beneficial effects on serum lipid profile in diabetic patients, the overall effect of pioglitazone is more pronounced as compared to rosiglitazone, metformin and sulphonylureas.
In addition, 70% of the elderly diabetics were on sulphonylurea, especially glibenclamide when they had hypoglycaemia.
Intensive blood-glucose control with sulphonylureas or insulin, compared with conventional treatment and risk of complications in patients with type 2 diabetes.
Two generations of sulphonylureas have been differentiated according to substitution pattern.
In this combination metformin reduces insulin resistance and sulphonylureas increase insulin production forming an ideal treatment options for these patients.
Although different diabetes medicines need to be taken at various times of the day, sulphonylureas, including gliclazide, should be taken with breakfast," advises Nitin.
Patients treated with metformin had a small but statistically signiY=cant improvement in survival compared with the non-diabetics, whereas those treated with sulphonylureas had a consistently reduced survival compared with nondiabetic patients.
Patients treated with metformin had a small but statistically significant improvement in survival compared with the cohort of non-diabetics, whereas those treated with sulphonylureas had a consistently reduced survival compared with non-diabetic patients.
Current management of increasing insulin sensitivity includes the usage of sulphonylureas, acarbose, or insulin.
Patients are then offered a class of drugs that is known as sulphonylureas in addition.
This finding suggests a therapeutic advantage of agents targeting FFARl, compared with sulphonylureas, which are associated with frequent occurrence of hypoglycemia.
This finding suggests a therapeutic advantage of agents targeting FFAR1, compared with sulphonylureas, which are associated with frequent occurrence of hypoglycemia.