sulfinpyrazone


Also found in: Dictionary, Wikipedia.

sulfinpyrazone

 [sul″fin-pi´rah-zōn]
a uricosuric compound used in gout to promote excretion of uric acid; administered orally. It also prolongs platelet survival and inhibits platelet adherence to subendothelial cells and prostaglandin synthesis and has been studied as an antithrombotic agent.

sulfinpyrazone

/sul·fin·py·ra·zone/ (sul″fin-pi´rah-zōn) a uricosuric agent used in the treatment of gout.

sulfinpyrazone

(sŭl′fĭn-pĭr′ə-zōn′)
n.
A drug, C23H20N2O3S, related to phenylbutazone, that promotes urinary excretion of uric acid and is used in the treatment of gout.

sulfinpyrazone

[sul′finpir′əzōn]
a uricosuric drug.
indications It is prescribed in the treatment of chronic gout and intermittent gouty arthritis.
contraindications Peptic ulcer, ulcerative colitis, renal dysfunction, or known hypersensitivity to this drug or to phenylbutazone prohibits its use. It is not usually given during an acute attack of gout.
adverse effects Among the more serious adverse effects are GI ulcers, blood dyscrasias, and dermatitis.

Sulfinpyrazone

A drug that corrects hyperuricemia by increasing the urinary excretion of urate.
Mentioned in: Gout

sulfinpyrazone

uricosuric agent used as an alternative to allopurinol in the long-term management of tophaceous gout

sulfinpyrazone (sul´finpir´əzōn´),

n brand name: Anturane;
drug class: uricosuric;
action: inhibits tubular reabsorption of urates, with increased excretion of uric acid; inhibits prostaglandin synthesis, which decreases platelet aggregation;
use: treatment of chronic gouty arthritis.
References in periodicals archive ?
49) Note: Related drugs included aspirin, sulfinpyrazone, and ticlopidine.
13) Unequivocally, benzbromarone, probenecid, losartan, sulfinpyrazone, and high doses of salicylates elevate uricosuric activity primarily through inhibition of URAT1.
John's Wort Primidone Sulfinpyrazone Weak/moderate Nefazodone Quinidine inhibitors Nevirapine Ranitidine Norfloxacin Sertindole Norfluoxetine Troleandomycin Omeprazole Verapamil Paroxetine Zafirlukast Propoxyphene Zileuton Strong inhibitors * Ketoconazole Ritonavir Nelfinavir Saquinavir * Requires dosage modification when used in combination with PDE5 inhibitor.
Underexcretion hyperuricemia; and allergy, intolerance, or contraindications to both probenecid and sulfinpyrazone.
Pharmacologic therapies include 1) uricosurics, such as probenecid, sulfinpyrazone and benzbromarone (used mostly in Europe), which increase the renal clearance of uric acid, 2) xanthine oxidase inhibitors such as allopurinol, which limit the formation of uric acid to yield a more water soluble chemical, and 3) anti-inflammatory medications, including nonsteroidal anti-inflammatory drugs (NSAIDs) and colchicine.
Drugs such as trimethoprim-sulfathiazole (TMP-sulfa), erythromycin, cimetidine, metronidazole, ketoconazole, fluconazole, itraconazole, amiodarone, and sulfinpyrazone all decrease the warfarin metabolism, which can increase prothrombin times and raise the international normalized ratio (INR).
If these agents are ineffective, or if patients develop tophi or kidney stones, consider adding a second agent that can lower the serum level of uric acid to below 7 mg/dL: allopurinol, probenecid, or sulfinpyrazone.
16] Drugs that potentiate warfarin's anticoagulant effect include amiodarone,[17] androgens,[18] cimetidine,[19,20] clofibrate,[21] disulfiram,[22] metronidazole,[23] phenylbutazone,[24,25] sulfinpyrazone,[26] thyroxine,[27] and trimethoprim-sulfamethoxazole.
Myers et al (9) in 1987 reported on a large multicenter trial of aspirin and sulfinpyrazone for unstable angina.