Galactocerebrosides and sulfatides are major constituent lipids of myelin sheath.
Low concentrations of cerebrosides and sulfatides during ischemia caused by decrease in intracellular pH can induce the release of lysosomal hydrolases (Mikulas et al.
Characterization of urinary sulfatides
in metachromatic leukodystrophy using electrospray ionization-tandem mass spectrometry.
Other possible serum, CSF, and urine markers include isoprostanes, sulfatides
, oxysterols, homocysteine, apolipoprotein E, alpha 1-antichymotrypsin, 3-nitrotyrosine, and more.
Determination of urinary sulfatides
and other lipids by combination of reversed-phase and thin-layer chromatographies.
MLD occurs where a person is deficient in an enzyme called Arylsulfatase, which is responsible for breaking down fats called sulfatides
into harmless chemicals
The mycolic acid-containing glycolipids, mannose-containing phospholipids, glycopeptidolipid mycosides, phenolglycolipid mycosides, and sulfatides
that are unique to mycobacteria have all been reported to stimulate immune responses in animals (40).