In pooled analyses, women given 3 or more doses of sulfadoxine
pyrimethamine in mid- to late pregnancy had babies that were 56 g (95% CI 29 - 83) heavier at birth than women given the standard 2 doses.
Traditionally, malaria is treated with antimalarial drugs such as chloroquine, oxinine, sulfadoxine
, pyrimethamine, and the latest, artemisinin, in combination with others.
Lastly, the first micronutrient surveillance did not investigate some important anaemia-prevention strategies such as presumptive treatment of malaria with sulfadoxine
pyrimethamine, and the uptake of insecticide-treated bed nets.
Others received pills combining sulfadoxine
and pyrimethamine, an old, inexpensive therapy still used extensively in Africa (SN: 11/11/06, p.
Chloroquine and quinine have "very limited use" for SBET, while other drugs such as mefloquine, atovaquone and proguanil (Malarone), and sulfadoxine
plus pyrimethamine (Fansidar) are acceptable for SBET.
The following drugs were checked: acetylsalicylic acid, acetaminophen, ibuprofen, dextropropoxyphen, fluoxetine hydrochloride, bromazepam, oxazepam, zolpidem, pindolol, atenolol, digoxin, meprobamate, theophylline, valproic acid, chloroquine, quinine, amodiaquin, mefloquine, sulfadoxine
, and pyrimethamine.
resistance in Plasmodium falciparum: what next?
Malawi abandoned the drug in 1993, and doctors there replaced it with an inexpensive combination pill containing sulfadoxine
The combination of sulfadoxine
and pyrimethamine is no longer recommended for prophylactic self-treatment.
ACT adult Kit (Artcsunato 50 mg 12tab + Sulfadoxine
(500mq) Pyrimethamine (25) mq 3 tab
vivax biology, most of the data have been gained through comparative studies investigating polymorphisms in orthologous genes encoding resistance to pyrimethamine (dhfr gene), sulfadoxine
(dhps gene), or chloroquine (chloroquine resistant transporter or mdr-1 genes).
15 years and aboveTablet Artesunate Two yearsTablet Sulfadoxine
plus Pyremethamine two years.