Pharmacologic class: Sulfonamide
Therapeutic class: Anti-infective
Pregnancy risk category C
Inhibits bacterial synthesis of folic acid by preventing condensation of pteridine with aminobenzoic acid through competitive inhibition of dihydropteroate synthetase
Lotion: 10% in 2-oz and 4-oz bottles
Ophthalmic solution: 10% in 5-ml and 15-ml dropper bottles
Indications and dosages
➣ Acne vulgaris
Adults and children ages 12 and older: Apply thin film topically to affected areas b.i.d.
➣ Superficial ocular infections (including conjunctivitis)
Adults and children ages 2 months and older: Initially, apply one to two drops of ophthalmic solution into conjunctival sac of affected eye q 2 to 3 hours. Taper by increasing dosing intervals as condition responds. Usual duration is 7 to 10 days.
➣ Adjunct in trachoma
Adults: Apply two drops of ophthalmic solution into conjunctival sac of affected eye q 2 hours; must be accompanied by systemic sulfonamide therapy.
• Hypersensitivity to drug or other sulfonamides
Use cautiously in:
• sulfite allergy
• dry eye syndrome.
• To avoid contamination, don't touch container tip to eye, eyelid, or any other surface.
EENT: conjunctival hyperemia, eye burning, stinging, tearing (ophthalmic form)
Skin: local irritation, erythema, itching and edema (topical form), photosensitivity reaction
Other: secondary infections
Drug-drug. Porfimer: increased severity of photosensitivity reaction, leading to excessive tissue damage
Silver preparations: precipitation
• Monitor patient for drug efficacy. Know that drug may be inactivated by purulent exudate.
• Tell patient to apply a thin film of lotion to affected areas, as prescribed.
• Teach patient how to apply ophthalmic form. Instruct him to always wash hands first and to clean eye area of discharge by wiping from inner to outer area before applying.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.