Other firms utilize technology that lastingly turns off CAR-T drugs using what is known as a suicide gene
So doctors tweaked cells from donors to carry a suicide gene
and a unique 'flag' on their outer surface.
To test the efficiency of NSCs in targeting and treating breast cancer, the researchers injected NSCs loaded with a suicide gene
(herpes simplex virus thymidine) into mice bearing breast tumors.
In vivo suicide gene
therapy - antitumour effect of PLTK47.
ALLIUM SATIVUM POTENTIATES SUICIDE GENE
THERAPY FOR MURINE TRANSITIONAL CELL CARCINOMA.
Their topics include genetic markers in breast tumors with hereditary predisposition, signaling pathways in cancer, epigenetics and cancer, suicide gene
therapy, and genotypes that predict or efficacy of anticancer drugs.
MINNEAPOLIS -- Researchers have pioneered the concept of using oncolytic adenovirus-mediated suicide gene
therapy as an adjuvant to conventional radiation therapy in the treatment of prostate cancer.
Kansas City, MO, announced that its Genopoietic subsidiary in Paris, France, has received a contract from the French Army to prepare a clinical trial of the company's thymidine kinase (TK) suicide gene
program for the prevention of graft versus host disease (GVHD) following allogeneic bone marrow transplantation.
Scientists have also had success with a related technique called suicide gene
These genes are known as suicide genes
because they will kill any cancer cell containing the suicide gene
in response to a pro-drug.
These will be engineered for suicide gene
expression to improve safety and for autocrine IL-2 production to ensure better survival and function.
Finally, the last mechanism, suicide gene
therapy, utilizes transgenes known as "suicide genes
," which selectively kill the cells they are expressed in, and are thus primarily used for cancer treatment.