suicide gene


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suicide gene

A gene that codes for a protein, usually an enzyme, that makes cells vulnerable to otherwise nontoxic substances or nutrients. Suicide genes can be introduced into cells during gene therapy. The technique is used in cancer therapy to make tumor cells susceptible to treatment with prodrugs, which only become active chemotherapeutic agents when they are metabolized within cells harboring the gene. Suicide gene therapy is also used in graft-versus-host disease to kill the activated donor T cells responsible for the immunological attack on the host.

suicide gene

a GENE coding for a product that can kill the CELL. It may be used as a BIOLOGICAL CONTAINMENT stratagem.
References in periodicals archive ?
Other firms utilize technology that lastingly turns off CAR-T drugs using what is known as a suicide gene .
So doctors tweaked cells from donors to carry a suicide gene and a unique 'flag' on their outer surface.
To test the efficiency of NSCs in targeting and treating breast cancer, the researchers injected NSCs loaded with a suicide gene (herpes simplex virus thymidine) into mice bearing breast tumors.
ALLIUM SATIVUM POTENTIATES SUICIDE GENE THERAPY FOR MURINE TRANSITIONAL CELL CARCINOMA.
Their topics include genetic markers in breast tumors with hereditary predisposition, signaling pathways in cancer, epigenetics and cancer, suicide gene therapy, and genotypes that predict or efficacy of anticancer drugs.
MINNEAPOLIS -- Researchers have pioneered the concept of using oncolytic adenovirus-mediated suicide gene therapy as an adjuvant to conventional radiation therapy in the treatment of prostate cancer.
Kansas City, MO, announced that its Genopoietic subsidiary in Paris, France, has received a contract from the French Army to prepare a clinical trial of the company's thymidine kinase (TK) suicide gene program for the prevention of graft versus host disease (GVHD) following allogeneic bone marrow transplantation.
Scientists have also had success with a related technique called suicide gene therapy.
These genes are known as suicide genes because they will kill any cancer cell containing the suicide gene in response to a pro-drug.
These will be engineered for suicide gene expression to improve safety and for autocrine IL-2 production to ensure better survival and function.
Finally, the last mechanism, suicide gene therapy, utilizes transgenes known as "suicide genes," which selectively kill the cells they are expressed in, and are thus primarily used for cancer treatment.