succinylcholine


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succinylcholine

 [suk″sĭ-nil-ko´lēn]
a neuromuscular blocking agent used as the chloride salt to aid in such procedures as endotracheal intubation and endoscopy, as an adjunct to surgical anesthesia, and in convulsive therapy; administered intramuscularly or intravenously.

suc·ci·nyl·cho·line

(sŭk'si-nil-kō'lēn),
A neuromuscular relaxant with short duration of action that characteristically first depolarizes the motor endplate (phase I block) but is often later associated with a curarelike, nondepolarizing neuromuscular block (phase II block); used to produce relaxation for tracheal intubation and during surgical anesthesia.

succinylcholine

/suc·ci·nyl·cho·line/ (suk″sĭ-nil-ko´lēn) a depolarizing neuromuscular blocking agent used as the chloride salt as an anesthesia adjunct and in convulsive therapy.

succinylcholine

(sŭk′sə-nĭl-kō′lēn)
n.
A crystalline compound, C14H30N2O4, formed by esterification of succinic acid with choline and used medically to produce brief but complete muscular relaxation during surgical anesthesia.

succinylcholine

Anesthesiology A potent, rapid depolarizing muscle relaxant that provides short-term paralysis for tracheal intubation during surgery, attenuating motor activity of seizures evoked by electroconvulsive therapy Complications Postoperative myalgia, transient ↑ in serum K+, ↑ in intraocular, intracranial, and intragastric pressure; malignant hyperthermia. See Cholinesterase, Dibucaine number, Depolarizing agent, Muscle relaxant.

suc·ci·nyl·cho·line

(sŭk'si-nil-kō'lēn)
A neuromuscular relaxant with short duration of action that characteristically first depolarizes the motor endplate (phase I block) but is often later associated with a curarelike, nondepolarizing neuromuscular block (phase II block); used to produce relaxation for tracheal intubation and during surgical anesthesia.

suc·ci·nyl·cho·line

(sŭk'si-nil-kō'lēn)
A neuromuscular relaxant with short duration of action that characteristically first depolarizes the motor endplate (phase I block) but is often later associated with a curarelike, nondepolarizing neuromuscular block (phase II block).

succinylcholine

a short-acting depolarizing neuromuscular blocking agent used as a muscle relaxant. Called also suxamethonium.

succinylcholine bromide
the pharmaceutical form of succinylcholine; can cause death by cardiac arrest in even healthy horses.
References in periodicals archive ?
S type homozygotes are extremely rare (1 in 10,000) and would have significant paralysis from a single dose of succinylcholine that may last more than four hours.
This study show that propofol in higher dose effectively reduces the incidence & severity of succinylcholine induced fasciculations and myalgia compared with thiopentone.
Myth: Atropine should be administered before succinylcholine for neonatal and pediatric intubation.
Rocuronium versus succinylcholine for rapid sequence induction of anesthesia and endotracheal intubation: a prospective, randomized trial in emergent cases.
Unlike acetylcholinesterase, BChE is capable of hydrolyzing exogenous carboxylic or phosphoric acid esters found in succinylcholine, aspirin, mivacurium, ester-type local anesthetics, amitriptyline, cocaine, heroin, and several anticonvulsant drugs (3).
Before the shortage of succinylcholine was resolved earlier this year, shortages of the agent also resulted in postponed surgeries at Veterans Administration Medical Centers.
A randomized controlled comparative study of rocuronium bromide versus succinylcholine for endotracheal intubation was undertaken to find out the efficacy of rocuronium bromide as a suitable substitute to succinlycholine.
They hand you a written report of an enzyme-linked immunosorbent assay, which tested negative for an allergy to succinylcholine.
The action of succinylcholine is to open sodium channels and depolarize the postsynaptic muscle membrane in the same manner as acetylcholine.
Dubai police last Sunday issued a statement saying the "killers used the drug succinylcholine to sedate al-Mabhouh before they suffocated him" and that "assassins used this method so that it would seem that his death was natural".
On Sunday, Khalfan's deputy, Khamis Mattar al-Mazeina, said in a statement the killers had used the drug succinylcholine "to sedate Mabhouh before they suffocated him.