succinate dehydrogenase


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suc·ci·nate de·hy·dro·gen·ase

a flavoenzyme that catalyzes the removal of hydrogen from succinic acid and converts it into fumaric acid; for example, succinate + FAD ⇄ fumarate + FADH2; this complex is a part of the tricarboxylic acid cycle.

muscle enzymes

the table lists some of the most often-mentioned enzymes present in skeletal muscle, with their locations and functions. Apart from actomyosin and myosin ATPases which are associated with the contractile mechanism, they are by no means specific to muscle, being present and highly active also in other tissues. See also Krebs cycle, muscle fibre types.
Table 1: Muscle enzymes
Name SiteCatalyses…
Actomyosin ATPase (amATPase) myosin head groups hydrolysis (Mg-dependent and triggered by rise in [Ca2+]) of terminal phosphate group of ATP when head-group is in interaction with actin, releasing energy that powers force- generation. (Compare myosin ATPase)
Creatine kinase (CK) cytoplasm transfer of phosphate group from creatine phosphate to ADP, producing ATP and creatine. Isoenzymes can be distinguished in blood when either skeletal or cardiac muscle has been damaged.
Hexokinase (HK) cytoplasm 'capture' of glucose after uptake from the blood, by conversion to the impermeant glucose 6-phosphate, in type 1 muscle fibres, which utilize glucose directly.
Lactate dehydrogenase (LDH) cytoplasm reduction of pyruvate to lactate when oxygen tension is low, and the converse when it is high. Isoenzymes can be distinguished in blood when either skeletal or cardiac muscle has been damaged.
Myosin ATPase (mATPase) myosin head groups hydrolysis (Ca2+ dependent, Mg2+ independent) of terminal phosphate group of ATP by head group alone, not interacting with actin (so not contraction-producing: cf actomyosin ATPase). Basic histochemical marker for fast vs. slow fibres.
Phosphofructokinase (PFK) cytoplasm conversion of fructose 6-phosphate to fructose 1,6-diphosphate; rate-limiting for glycolysis, and sensitive to very many stimulatory and inhibitory influences.
Phosphorylase (PPL) cytoplasmremoval of hexose units, one at a time, from glycogen, to form glucose 1-phosphate: rate-limiting enzyme of, and histochemical marker for, glycogenolysis.
Pyruvate dehydrogenase (PDH) mitochondrial envelope oxidative decarboxylation of pyruvate (from cytoplasm) to form acetyl CoA, which thence feeds into tricarboxylic acid (Krebs) cycle
Sarcoplasmic reticulum ATPase (srATPase) SR membrane pumping of [Ca2+] back into SR after its electrically stimulated release
Succinate dehydrogenase (SDH) mitochondrial inner membrane oxidation of succinate to fumarate, in tricarboxylic acid (Krebs) cycle. Histochemical marker for aerobic capacity.

succinate

any salt of succinic acid.

succinate dehydrogenase
an enzyme of the TCA cycle, located in the inner mitochondrial membrane that splits off hydrogen from succinic acid.
References in periodicals archive ?
Some of these enzymes such as peroxidases, succinate dehydrogenases and polyphenoloxidases act as the stress induced enzymes which also indicate the protection of the algal species form unfavorable conditions.
Structure and function of succinate dehydrogenase and fumarate reductase.
Mitochondrial myopathy with succinate dehydrogenase and aconitase deficiency: abnormalities of several iron-sulfur proteins.
Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency.
Low succinate dehydrogenase (SDH) activity in a patient with a hereditary myopathy with paroxysmal myoglobinuria.
Preparation of succinate dehydrogenase and reconstitution of succinate oxidase.
SDHB, succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA)] can provide more cost-effective targeting, I believe that universal testing is required to detect all patients harboring germline mutations.
11] Human genes: VHL, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase; SDHD, succinate dehydrogenase complex, subunit D, integral membrane protein; MAX, MYC associated factor X; TMEM 127, transmembrane protein 127; SDHA, succinate dehydrogenase complex, subunit A, flavoprotein (Fp).
Most recently mutations of the genes for succinate dehydrogenase complex assembly factor 2 (SDHAF2); transmembrane protein 127 (TMEM127); and succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA) have been identified as further hereditary causes of PPGLs (6-8).
Clinical presentations, biochemical phenotypes, and genotypephenotype correlations in patients with succinate dehydrogenase subunit B-associated pheochromocytomas and paragangliomas.
10] Human Genes: RET, ret proto-oncogene; VHL, von Hippel-Lindau tumor suppressor; NF1, neurofibromin 1; SDHB, succinate dehydrogenase complex, subunit B, iron sulfur (Ip); SDHD, succinate dehydrogenase complex, subunit D, integral membrane protein; SDHC, succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa; SDHAF2, succinate dehydrogenase complex assembly factor 2; TMEM127, transmembrane protein 127; SDHA, succinate dehydrogenase complex, subunit A, flavoprotein (Fp).
024 4 Succinate dehydrogenase 10 200 5 Cytochrome c oxidase 0.