succimer

succimer

 [suk´sĭmer]
a chelating agent that is an analogue of dimercaprol, administered orally in the treatment of heavy metal poisoning. A complex with technetium 99m is used in renal function testing.

succimer

/suc·ci·mer/ (suk´sĭ-mer) a heavy metal–chelating agent that is an analogue of dimercaprol, used in the treatment of lead poisoning; also complexed with technetium Tc 99m and used in renal function testing.

succimer

A water-soluble chelator administered per os for heavy metal poisoning–eg, lead poisoning in children > 2.17 µmol/L–US: 45 µg/dl or adults with lead poisoning due to gunshot wounds. See Lead, Saturnine gout.

Succimer (Chemet)

A drug used to remove excess lead from the body.
Mentioned in: Lead Poisoning
References in periodicals archive ?
Today, succimer is used most often for chelation, although calcium disodium EDTA and dimercaprol are still used in some cases.
Although approved for the treatment of lead poisoning, succimer is used off-label for treating mercury toxicity (5).
The treatment of lead poisoning from gunshot wounds with succimer (DMSA).
Succimer treatment and calcium supplementation reduce tissue lead in suckling rats.
The analysis of patient data from 1,280 individuals in nine cohort studies also showed a polymorphonuclear cell count of greater than 60% nearly doubled the risk while the presence of grades IV-V vesicoureteral reflux was associated with a 22-fold increase in the likelihood of renal scarring, defined as presence of photopenia on a technetium Tc 99m succimer renal scan.
There are six agents available to treat heavy metal (arsenic, gold, iron, lead, and mercury) intoxication: de-ferasirox (iron), deferoxamine (iron), dimercaprol (arsenic, gold, lead, and mercury), edetate calcium disodium (lead), penicillamine (copper and mercury), and succimer (lead).
Succimer chelation improves learning, attention, and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure.
A comparison of sodium calcium edentate (edentate calcium disodium) and succimer (DMSA) in the treatment of organic lead poisoning.
Some families have turned to succimer as an alternative therapy for treating autism.
Lead induced oxidative stress and its recovery following co-administration of melatonin or n-acetylcysteine during chelation with succimer in male rats.
Se han utilizado diversos agentes como terapia quelante en la intoxicacion con mercurio, entre ellos: succimer, dimercaprol, D-penicilamina y N-acetilcisteina; en Colombia se dispone de los dos ultimos.