subthalamic nucleus

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Related to subthalamic nucleus: striatum, globus pallidus, caudate nucleus

sub·tha·lam·ic nu·cle·us

a circumscript nucleus, shaped like a biconvex lens, located in the ventral part of the subthalamus on the dorsal surface of the peduncular part of the internal capsule immediately rostral to the substantia nigra. The nucleus receives a massive topographic projection from the lateral segment of the globus pallidus and a somatopically organized projection from the ipsilateral motor cortex; a smaller bundle of afferents from the centromedian nucleus of the thalamus terminates in the rostral part of the nucleus The subthalamic nucleus projects to both pallidal segments, to the pars reticulata of the substantia nigra, and in a small way to the ipsilateral pedunculopontine nucleus.

subthalamic nucleus

a biconvex mass of gray matter on the medial side of the junction of the internal capsule and the crus cerebri. Its chief connections are with the globus pallidus.

subthalamic nucleus

A basal ganglia nucleus that is found under the thalamus in the base of the diencephalon; it lies between the thalamus and the cerebral peduncle, just rostral to the substantia nigra. The subthalamic nucleus is a satellite of the globus pallidus with which it has reciprocal connections. Lesions of the subthalamic nucleus on one side of the brain produce hemiballismus.
See also: nucleus


Jules B., French physician, 1828-1897.
centre médian de Luys - Synonym(s): centromedian nucleus
corpus luysi - Synonym(s): subthalamic nucleus
Luys body - Synonym(s): subthalamic nucleus
Luys body syndrome
nucleus of Luys - Synonym(s): subthalamic nucleus
References in periodicals archive ?
Chronic subthalamic nucleus stimulation reduces medication requirements in Parkinson's disease.
Effects of subthalamic nucleus stimulation on motor cortex plasticity in Parkinson disease," Neurology, vol.
Comparison of three methods of targeting the subthalamic nucleus for chronic stimulation in Parkinson's disease.
Researchers concluded that both the globus pallidus interna and the subthalamic nucleus areas of the brain "are viable DBS targets for treatment of motor symptoms, but highlight the importance of nonmotor symptoms as determinants of quality of life in people with Parkinson's disease.
2007) NMDA-mediated release of glutamate and GABA in the subthalamic nucleus is mediated by dopamine: an in vivo microdialysis study in rats.
22) Note that in one patient after subthalamic nucleus (STN) DBS, pulse-modulated radiofrequency diathermy applied to the maxilla produced permanent diencephalic and brainstem lesions leading to a vegetative state.
In a second study, a prospective, randomized trial called COMPARE (Comparison of Best Medical Therapy and Deep Brain Stimulation of Subthalamic Nucleus and Globus Pallidus for the Treatment of Parkinson's Disease), 6-month data on 45 of 52 patients (mean age 61 years) showed no significant difference between 22 STN and 23 GPi patients in seven of the eight subscales of the visual analog mood scale, said Dr.
Introduction: Subthalamic nucleus stimulation for patients with medically refractory Parkinson disease is expanding.
They recommend that deep brain stimulation of the subthalamic nucleus "may be considered" to improve Parkinson's disease symptoms and reduce medication use.
The dopaminergic inputs of the substantia nigra to the striatum are also shown, as are the interconnections of the globus pallidus with the subthalamic nucleus.
A cross-sectional study of DBS of the subthalamic nucleus and the internal segment of the globus pallidus on force control and coordination revealed that stimulation led to increases in maximum pinch force production and improvements in force control parameters in a bimanual task.