substrate inhibition

sub·strate in·hi·bi·tion

inhibition of an enzyme activity by a substrate of the reaction catalyzed by that enzyme; often, this type of inhibition occurs at elevated substrate concentrations in which the substrate is binding to a second, non-active site on the enzyme.
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This is consistent with work that demonstrated substrate inhibition via an allosteric binding site (Zhang et al.
On the other hand, the Haldane model could be taking into account a possible substrate inhibition effect at a higher concentration even though the dependence [OUR.
Substrate inhibition appeared in SHF when cassava starch reached 70 g/L due to the relatively weak toleration to initial sugar concentration.
Biosensor response at mixed enzyme kinetics and external diffusion limitation in case of substrate inhibition, Nonlinear Analysis: Modeling and Control 11(4): 385-392.
Some inhibitory effect is revealed in the presence of excess of ATP, while for the peptide counterpart of the reaction no substrate inhibition was observed within the concentration interval used.
The observation of substrate inhibition due to phenol can be modeled using substrate inhibition models described in literature16.
Adsorption also caused a lowering of the phenol concentration in solution with a concomitant reduction in the substrate inhibition effect on cell growth.
The dose-response data in Figure 5 are certainly consistent with the regulation of enzymatic pathways, where lower doses might be expected to stimulate enzymatic activity and higher concentrations may inhibit enzymatic activity via substrate inhibition.
As shown in Table 1, the CaN activity increased with the incubation time for all substrate concentrations investigated, and there was no indication of substrate inhibition.
As the following experimental study will be based on the use of protein kinase A, the present reaction scheme takes into consideration also the phenomenon of substrate inhibition by the excess of ATP (substrate A), assuming the formation of both EAA and EAAB complexes.
In this case, the specific growth had substrate inhibition as well as inhibition by toxin accumulation.