b) Macular image with OCT scan showing subretinal
fluid and possible choroidal neovascularisation
The projects builds on data previously obtained by the coordinator that a single combined subretinal
administration of dual aav vectors, Each packaging one of the two halves of a myo7a expression cassette, Results in myo7a reconstitution and therapeutic efficacy in a mouse model of ushib.
B-scan ultrasound revealed vitreous opacity, retinal detachment, and subretinal
lesions in the right eye.
SF0166 also demonstrated clinically significant biological activity, as assessed by a panel of three leading retinal physicians, in 9 of the 42 patients who completed the study evidenced by decreases in central retinal thickness and/or subretinal
fluid by spectral domain optical coherence tomography.
These include right-angle veins, subretinal
and outer retinal neovascularization, and vascular invasion of the foveal avascular zone.
The dilated pupil fundus examination revealed exudative retinal detachment (retinal detachment with no visible retinal tears, holes or breaks) with subretinal
haemorrhage and a choroidal mass ~2 disc diameters superior from her optic disc (Fig.
Eyes with anterior segment seedlings, rubeosisiridis, posterior synechiae, complicated cataract, ciliary body involvement and retinal detachment with massive vitreous and/or subretinal
seedlings were excluded from the study.
OpRegen is an investigational therapy in which retinal pigment epithelial (RPE) cells are transplanted into the subretinal
space, where they are intended to replace missing RPE cells.
Each patient will receive a single subretinal
injection of AAV-XLRPGR gene therapy.
El HCD es una manifestacion rara dentro del espectro del SSW y puede estar asociado a desprendimiento exudativo de retina y edema macular cistoideo con disminucion de agudeza visual, manifestaciones que son ipsolaterales al nevusflammeus como fue observado en esta paciente cuya alternativa terapeutica es la braquiterapia con placa rutenio-106 capaz de producir esclerosis y disminucion del tamano de la lesion con reabsorcion de liquido subretinal
Anatomical success was defined as attachment of sensory retina with retinal pigment epithelium with no residual subretinal
Fundoscopy revealed granular pigmentary changes in subretinal