Neurogenesis in the adult brain is a normal process to generate new neurons and occurs throughout life in restricted brain regions, which is called neurogenic regions, such as the subgranular
zone (SGZ) of the dentate gyrus (DG) of the hippocampus and the subventricular zone of the lateral ventricle in mammals.
Progenitor cells were counted using a 40x objective throughout the rostrocaudal extent of the subgranular
zone (SGZ) which is structurally located between granular cell layer and hilus of the DG of both sides.
En el caso de la proliferacion en hipocampo adulto, se sabe que las celulas progenitoras que son originadas en la zona subgranular
del giro dentado tienen caracteristicas morfologicas de celulas gliales (Seri et al.
Ahora se conoce que la neurogenesis se lleva a cabo en los ventriculos laterales del cerebro y en la zona subgranular
del giro dentado, en el hipocampo.
En cuanto a la interferencia en la neurogenesis, se sabe que el hipocampo es uno de los dos sitios mas activos para este proceso en el cerebro de los mamiferos, y la proliferacion de celulas precursoras en la zona subgranular
genera celulas que migran a la capa granulada y se diferencian en fenotipos neuronales y gliales de los que se originan nuevas celulas.
Neurogenesis occurs in neural stem cells of the subventricular zone of the lateral ventricles, subgranular
layer of the dentate gyrus, and olfactory bulbs.
The hippocampal BrdU positive cells of the granular cell undcrlayer of dentate gyrus on the 6 brain slices of each rat was counted under light microscope, using the total cell quantity of bilateral hippocampal subgranular
zones (SGZ) on the 6 slices to reflect the proliferation status of cells in SGZ.
Of late, however, evidence has been found showing that adult neurogenesis takes place in two areas: the subventricular zone of the olfactory bulb and subgranular
zone in the hippocampus's dentate gyrus.
1) New cells in the dentate gyrus divide along the subgranular
zone during early development, migrate into the granule cell layer, and become neurons in shape (morphology) and gene expression (phenotype).
Anolis casildae was reported previously to possess a single, keeled and elongate superciliary scale extending the length of the eye followed by a series of subgranular
scales, and this feature was used to distinguish it from a number of other species, Individuals examined and discussed in this paper differ in having a second enlarged superciliary scale behind the first, and sometimes even a third small superciliary scale.
There was good graft survival, with extensive migration of BrdU-positive cells either specifically within the subgranular
layer of the dentate gyrus (DG); or throughout the striatum, in particular toward the globus pallidus.
Neural stem cells (NSCs) and neural progenitor cells (NPCs) in the adult brain are mainly located in two regenerative niches: the subventricular zone (SVZ) flanking the lateral ventricles and the subgranular
zone (SGZ) of the dentate gyrus (DG) in the hippocampus.