It is known that uterine epithelium undergoes renewal during the proestrus of estrous cycle (11) and we hypothesized that the increases in RHAMM immunoreactivity in the epithelium and subepithelium may be related to mitosis of the uterine stem cells which are found in both the epithelial and stromal compartments of the endometrium (13).
Because of the fundamental role for RHAMM in mediating and HA-induced cell migratory response, the strong RHAMM immunoreactivity in both uterine epithelium and subepithelium of the proestrus cycle may be related to stem cell motility.
Nevomelanocytes can be organized into intraepithelial nests of oval cells (type A), sheets of oval to cuboidal cells (type B), and spindlelike cells in the subepithelium
(type C) (Figure 1, A through D).
Meanwhile, the slides and paraffin blocks of the previous gum biopsy were obtained for review, which showed dense monotonous infiltrates by blasts, with round nuclei and scanty cytoplasm in the subepithelium
of the gum with frequent mitoses.
showed dense lymphocytic infiltrate.
They also enter the epithelium faster and are translocated in greater proportion to the subepithelium
space compared with fine particles (13).
the overall number of c-KIT (CD117)-positive cells within the subepithelium
of large airways was substantially greater in obliterative bronchiolitis cases when compared to control cases
The subepithelium was designated as the connective tissue immediately surrounding each individual airway, including muscular layer and adventitial connective tissue.
The 4 cases of obliterative bronchiolitis as a group showed a dramatic increase in staining for c-KIT (CD117)-positive mast cells within the subepithelium of small airways (122.
The ratio of mast cells in the subepithelium to mast cells in the epithelium of small airways was markedly increased in cases of obliterative bronchiolitis when compared to this same ratio in cases of asthma and emphysema (65.
c-KIT (CD117) staining appeared to have a relationship to the individual airway involvement in the case of obliterative bronchiolitis from ammonia exposure (case B), as was made evident by the difference between staining in the subepithelium of 9 airways with fibrosis (51.
Histologic examination revealed infiltration of the subepithelium
by malignant melanocytes containing cytoplasmic and nuclear brown pigment (Figure 3).