stromelysin


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stromelysin

(strō′mă-līs-ĭn),

MMP-3

Member of the matrix metalloproteinase family of enzymes that plays a major role in the degradation of proteoglycans, gelatin, and other constituents of the extracellular matrix. Two forms of stromelysin have been described, stromelysin-1 and -2. Stromelysin-1 degrades proteoglycans, gelatin, fibronectin, laminin, collagen types III, IV, IX, and X. Stromelysin-2 degrades proteoglycans, fibronectin, laminin, and collagen type IV.
References in periodicals archive ?
In situ hybridization studies of stromelysin and collagenase messenger RNA expression in rheumatoid synovium.
Four members of this family have been identified, among which TIMP-1 acts against all members of the collagenase, stromelysin, and gelatinase classes of MMPs (9).
Immunoassays for the detection of human collagenase, stromelysin, tissue inhibitor of metal loproteinases (TIMP) and enzyme-inhibitor complexes.
Plaque rupture is mediated by such enzymes as collagenase, gelatinase, and stromelysin, which degrade components of the interstitial matrix.
Some MMPs, such as gelatinases, stromelysins and collagenase-3, are believed to play key roles in the invasion, metastasis and growth of many malignant tumors.