RESULTS: The objective was to compare haemodynamic variables between the propofol group and the etomidate group during induction and orotracheal intubation, which includes the heart rate, arterial pressures (Systolic, diastolic, and mean), cardiac index, pulmonary artery pressures (Systolic, diastolic, and mean), central venous pressure, stroke volume index, systemic vascular resistance index, pulmonary vascular resistance index, left ventricular stroke work index, and right ventricular stroke work index.
Comparison of Left Ventricular Stroke Work Index (LVSWI) between two groups is shown in table 3 and chart 4.
Comparison of Right Ventricular Stroke Work Index (RVSWI) between two groups demonstrate that induction resulted in 16% reduction in group P (P>0.
In the Dyspnea Differential Study, the BioZ System's measurements of cardiac index, stroke index, and left stroke work index
were studied and compared to the clinical diagnosis of four physicians, independently reviewing each patient's chart and blinded to the BioZ System data.
While the most recently completed, single-dose congestive heart failure trial showed average improvement of 15-20 percent in cardiac index and left ventricular stroke work index (both are measures of heart function), these effects were, in general, less robust than those observed in the CABG trial, largely due to the numerous other cardiovascular drugs these patients were taking.
CPC-111 has now demonstrated positive effects on numerous efficacy parameters in CABG patients, indices of both heart damage such as CKMB levels and a variety of heart function measures such as cardiac index, left ventricular stroke work index, pulmonary artery wedge pressure and, most recently, pulmonary vascular resistance.