Different responsiveness of striatonigral
and striatopallidal neurons to L-Dopa after a subchronic intermittent L-Dopa treatment.
Striatal D2 receptor status in patients with Parkinson's disease, striatonigral
degeneration, and progressive supranuclear palsy measured with 11C-raclopride and positron emission tomography.
It has been documented that DA from substantia nigra neurons excites striatonigral neurons, while another neurotransmitter, acetylcholine (ACh) from striatal cholinergic neurons, opposing DA action, inhibits striatonigral neurons (12).
Although the focus on the pathogenesis of PD has related to dopaminergic deficits that most of current symptomatic PD therapies attempt to correct, a proper balance between dopaminergic and cholinergic systems is required for the normal function of striatonigral neurons (28).
MSA was originally divided into Shy-Drager syndrome, striatonigral
degeneration, and olivopontocerebellar atrophy, but this distinction is no longer made.
degenerations, putaminal pigments and nosology.
Topographic intermingling of striatonigral
and striatopallidal neurons in the rhesus monkey.
degeneration and Parkinson's disease: a comparative clinical study.
The other two are striatonigral
degeneration and olivopontocerebellar atrophy.
In 1969, Oppenheimer used the term multiple system atrophy to describe conditions comprising striatonigral
degeneration (SND), olivopontocerebellar atrophy, (OPCA), and Shy-Drager syndrome (SDS; Quinn, 1989).
Subsequently, following further investigations, this patient was re-diagnosed with striatonigral
degeneration, a multiple system atrophy.