3]H] Dopamine uptake was determined in rat striatal
synaptosomal preparations based on the method detailed by Fleckenstein et al.
Radiological and pathological changes in hemiballism-hemichorea with striatal
DAT imaging reveals reduced presynaptic neuronal degeneration in PD and other parkinsonian syndromes, even when clinical features are subtle, while conditions such as essential tremor have normal striatal
DAT density (Fig.
Hence, ROI analysis showed that compared to controls, cannabis users displayed marginally higher levels of brain activity in striatal
regions during the anticipatory stages of the MID task.
Correlation of alcohol craving with striatal
dopamine synthesis capacity and [D.
Alternatively, individuals with FASD may overactivate prefrontal cortical regions when engaging inhibitory control in order to offset the effects of structural damage to striatal
This significant neuroprotection was not evident, however, when brain weight, striatal
lesion volume, and neuronal density measures for NT-3, were compared (see Table 2).
1987) and increases in striatal
GABA levels in animal models of PD, such as 6-hydroxydopamine (6-OHDA) (Bruet et al.
The development of the new brain-dedicated, high-resolution PET scanner (ECAT HRRT, Siemens Medical Solutions, Knoxville, TN) that provides images with enhanced resolution, step four in fails to segment the striatal
Evidence for striatal
dopamine release during a video game," Nature 393.
Among their topics are insulin receptor substrate signaling in the central nervous system from embryonic development to aging, G protein-coupled receptor hetero-dimerization as a molecular determinant of neuronal activity, the role of noradrenaline on interpersonal functioning, reversible immortalization for the expansion of neural cells, whether deficiency in striatal
dopamine action is an omen for Parkinson's disease, and molecular mechanisms underlying the inhibition of axonal regeneration after central nervous system injury.
Local administration of DOPAL destroys substantia nigra neurons (4); however, subacute neuropharmacologic manipulations expected to increase striatal
DOPAL generation do not affect local dopaminergic innervation (10).