streptozotocin


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streptozotocin

(strĕp′tə-zŏt′ə-sĭn)
n.
An antibiotic, C8H15N3O7, produced by an actinomycete (Streptomyces achromogenes), used primarily to treat pancreatic tumors affecting the Islets of Langerhans. Also called streptozocin.

streptozotocin

Oncology An alkylating nitrosurea derivative used to treat lymphomas and other CA Adverse effects Renal tubular dysfunction, glycosuria, hypoglycemia

streptozocin, streptozotocin

a nitrosurea compound with antineoplastic activity, derived from Streptomyces achromogenes; used principally in the treatment of islet-cell tumors of the pancreas.
References in periodicals archive ?
Group I: Normal Control (NC) receiving no treatment/supplementation; Group II: Diabetic control: rats were injected a single dose of streptozotocin intraperitoneally.
Overnight fasting animals were made diabetic by a single intraperitoneal injection of freshly prepared streptozotocin (STZ) (65 mg/kg) dissolved in 0.
GC-MS analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats.
To the best of our knowledge, this is the first work that evaluates the effect of biologically eco-friendly synthesized silver/gold composite nanoparticles coated with cinnamon powder extract (SG JF) to control the body weight and the hyperglycemic conditions in streptozotocin (STZ) induced diabetic rats.
Diabetes is induced in mice by using a single intraperitoneal injection of Streptozotocin with a dose of 40 mg/kg body weight in 10 mmol/l sodium citrate buffer with pH=4.
Rats in EDB group were kept fasting for twelve hours then rendered type-1 diabetic by single dose intraperitoneal injection of 80 mg/ kg body weight streptozotocin (STZ) freshly prepared in ice-cold 0.
Comparing the blood sugar level in Streptozotocin induced diabetic rats, honey administered animals showed significant reduction of blood glucose level which is as near as glibenclamide administered rats at (P<0.
Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat.
Diabetes was induced in the virgin female albino rats of groups (II) to (IV) by a single dose of intraperitoneal administration of streptozotocin (40 mg/kg).
In Streptozotocin induced diabetes rats model, MFME treatment enhanced plasma insulin levels by 69.