streptogramin


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streptogramin

(strĕp-tō-gram'in),
A synthetic protein that breaks down DNA, used to thin out the pulmonary secretions of patients with cystic fibrosis.

strep·to·gra·min

(strep'tō-gram'in)
A mixture of two structurally distinct compounds, type A and type B, which act at the level of inhibition of translation through binding to the bacterial ribosome; separately bacteriostatic but bactericidal in appropriate ratios. Antibiotics quinupristin and dalfopristin are both streptogramins.

streptogramin

(strĕp″tō-grăm′ĭn)
Any of a class of antibiotics effective against gram-positive bacteria that bind to the bacterial ribosome and inhibit protein synthesis. An example is the combination antibiotic quinupristin-dalfopristin.
References in periodicals archive ?
The ermB gene (which confers the macrolide lin cosamide streptogramin B phenotype) and the tetM gene (which confers tetracycline resistance) were detected by PCR.
Resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone antibiotics.
Makrolid, ketolid, linkozamid (linkomisin, klindamisin gibi) ve streptogramin B gibi antibiyotikler stafilokokal ribozo-ma baglanip protein sentezini inhibisyonuna yol acar.
These are the injectable beta-lactamase inhibitor, NXL104 and the oral streptogramin antibiotic, NXL103.
Aminoglycosides: amikacin, gentamicin, netilmicin and tobramycin, arbekacin (2000) for MRSA, streptogramin, quinapristine/dalfopris (1999) for VRE (E.
Dalfopristinquinupristin (RP 59500), a streptogramin antibiotic, is the first antibiotic approved for the treatment of patients with serious or life-threatening infections associated with vancomycin-resistant E.
The first involves alterations in antimicrobial transport (efflux), which is encoded by the mef(A) gene (M-phenotype) and generally confers low-level resistance (MIC 1-16 mg/L) to 14- and 15-membered macrolides, but not lincosamides and streptogramin B.
A streptogramin antibiotic for infections caused by vancomycin-resistant Enterococcus faecinm (VREF) bacteria, when no alternative is available.
pyogenes'in makrolid direnci pek cok sayida farkli gen tarafindan duzenlenmektedir, bu genler makrolidlerle birlikte, linkozamidler ve streptogramin B'ye (MLS) karsi farkli seviyelerde direncten de sorumludurlar.
NXL103, as a member of the Streptogramin class of antibiotics, has a unique mode of action, with its two components acting synergistically to inhibit the bacterial ribosome.
Quinupristin/dalfopristin is the first injectable streptogramin to be marketed in the United States.