5,6) Characteristics of these diseases include a high proportion of IgG4-positive plasma cells, predominantly T-lymphocytic infiltrate, storiform
fibrosis, and venulitis.
The cells are profoundly pleomorphic and arranged in a storiform
, haphazard architecture.
6-7,10) The histologic features are the same for all organs involved and include: dense lymphoplasmacytic infiltration rich in IgG4-positive plasma cells and eosinophils, obliterative phlebitis and storiform
Immunoglobulin G4-related disease is a chronic relapsing systemic fibroinflammatory disease that can affect any organ with a common key pathological feature including tendency to form inflammatory lesions rich in IgG4-positive plasma cells, storiform
fibrosis, phlebitis, and often an elevated IgG4 serum concentration (in 60-70% of patients).
Microscopic examination showed that the tumor was composed of elongated spindle cells displaying a patchy and a faint storiform
Three main histopathologic patterns of IMT have been described: (1) a myxoid/vascular pattern (Figure 2, A) characterized by spindle/stellate myofibroblasts with abundant eosinophilic cytoplasm and vesicular nuclei; (2) a compact, spindle cell proliferation (Figure 2, B)--sometimes with some ganglion-like cells--arranged in fascicular or storiform
patterns, with varying degrees of cellularity; and (3) a hypocellular, fibrous pattern (Figure 2, C), displaying abundant collagen, plasma cells, lymphocytes, and eosinophils (similar to desmoid fibromatosis).
Shave biopsy of this nodule showed thickened, eosinophilic collagen bundles arranged in a storiform
fashion typical of a sclerotic fibroma.
Microscopic examination of the removed specimen revealed a cellular lesion characterized by a proliferation of uniform spindle-shaped cells in a vague but prominent storiform
pattern, which represented the classic appearance of nonossifying fibroma.
The histopathological report showed an arrangement of spindle cells in a storiform
pattern with Verocay bodies interspersed with myxomatous areas.
Benign fibrous histiocytoma has predominant pattern of storiform
, cellular fibrous-tissue stroma.
Malignant fibrous histiocytoma is characterized by a mixture of spindle (fibrous) cells and round (histiocytic) cells arranged in a storiform
pattern, with frequent giant cells and areas of pleomorphism.
There is a highly vascular fibrous connective tissue stroma arranged in a storiform
to whorled pattern, and it contains osteoclast-type multinucleated giant cells (figure 3).