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storage lesionTransfusion medicine The constellation of changes occurring in a unit of packed red cells during storage. See Red cell preservatives.
↑ Ammonium to 470 µmol/L–US: 800 µg/dL
↑ Free Hb in plasma from 82 to 6580 mg/L–US: 8.2 to 658 mg/dL
↑ K+ from 4.2 to 78.5 mmol/L–US: 4.2 to 78.5 mEq/L
↓ ATP from 100% to 45%
↓ 2,3 DPG to < 10% of original levels–replenished within 24 hours of transfusion
↓ Labile proteins, eg complement, fibronectin and coagulation factors ↓ to negligible
↓ Na+ from 169 to 111 mmol/L–US: 169 to 111 mEq/L
↓ pH from 7.6 to 6.7
Adverse physiologic effects of stored blood is negligible in the absence of a previous compromise of the Pt's–recipient's status
In blood banking and transfusion therapy, the biochemical and structural degradation of blood cells that occurs over time.
See also: lesion