stop codon


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ter·mi·na·tion co·don

trinucleotide sequence (UAA, UGA, or UAG) that specifies the end of translation or transcription. Compare: amber codon, ochre codon, umber codon.

stop codon

n.
Any of three codons, UAA, UAG, or UGA, that signal the termination of the synthesis of a protein. Also called chain termination codon, termination codon.

stop codon

Any of the 3 codons (or triplets of nucleotides—UAA, UAG and UGA) on an mRNA molecule which lack a cognate aminoacyl tRNA—i.e., do not code for an amino acid and thus signal the end of protein synthesis. When ribosomes hit a stop codon, mRNA transcription is terminated, causing polypeptide synthesis to stop and the ribosome to dissociate from the mRNA.

stop codon

Any one of three nucleotide triplets which marks the end of every gene and indicates that protein synthesis ends at that point. The three stop codons are UAG (the amber codon), UAA and UGA. U is uracil, A is adenine and G is guanine.

stop codon

see NONSENSE CODON.
References in periodicals archive ?
The presence of premature stop codons in some of the nad2 and coI sequences of the familial analysis is striking and is the strongest argument for nuclear pseudogenes, but pseudogenes in the nuclear genome would have to both occur at a low enough frequency for the male contribution to be unobservable within these data but also have undergone enough duplication to account for the observed haplotype diversity.
This residue is related to the presence of a SEC insertion sequence (SECIS) in the corresponding mRNA that allows the translation of the UGA codon of the catalytic site as SEC instead of as a STOP codon (Brigelius-Flohe, 1999; Brigelius-Flohe and Maiorino, 2013).
The sequence anomaly disrupts the reading frame and introduces a premature stop codon, resulting in the majority of the protein not being translated.
Translation proceeds sequentially along the mRNA molecule from the start codon nearest the ribosome-binding site terminating at stop codons and reinitiating at the next start codon.
According to the stop and start codons, exon can be classified as: (i) a single exon gene which starts with a start codon and ends with a stop codon, (ii) an initial exon that begins with a start codon and ends with a donor site, (iii) a terminal exon that starts with an acceptor site and ends with a stop codon, (iv) and an internal exon that starts with an acceptor site and ends with a donor site [22].
C146X mutation causes a stop codon at cysteine 146 of exon 4, giving rise to a truncated LDL receptor.
These events led to the occurrence of a stop codon at positions corresponding to amino acids 39, 74, or 83.
Introduction of stop codon and consistent inheritance of the mutation with the disorder indicated its pathogenic nature.
The yearlong trial has only been made available to patients with a rare form of Duchenne muscular dystrophy as it just targets a particular type of gene fault, called a stop codon mutation.
Although over 300 different mutations have been identified as the cause of thalassemia, (2) nearly all of the mutations can be classified into one of five categories: deletions, promoter mutations, nonsense mutations, stop codon mutations, and splice site mutations .
2002) reported mutations in the DUOX2 gene, resulting in premature stop codon, in four CH patients with unexplained iodide organification defects.
Hawley and Mori (1999) explain how codons represent messages for other amino acids in their explanation of translation, which usually begins at the first start codon (AUG) encountered by the ribosome, connecting the corresponding amino acid to that codon; the ribosome continues to read the mRNA until it meets a stop codon (UAA, UGA, or UAG), called that because these codons do not represent amino acids and signal the ribosome to stop reading (p.