Low dose colchicine binding to beta-tubulin results in curved tubulin dimer and prevents it from adopting a straight structure, due to a steric
clash between colchicine and beta-tubulin.
This kind of observation from the objective measurement of pH comes to strengthen the model of the colloid particle protection shield, which is acting through the mechanism of steric
hindrance rather than ionic colloid protection, although it is obviously necessary to do additional work and provide more details in its support.
Amino acids descriptors such as Divided Physico-chemical Property Scores (DPPS), Vectors of Hydrophobic, Steric
and Electronic properties (VHSE) were applied to QSAR study of 214 tripeptides.
Scientists at the University of Kentucky tested their hypothesis that steric
hindrance and interfacial myofibrillar proteins, when compared with the continuous phase, can more effectively protect oil droplets against oxidative changes.
A pharmacophore, for example, as defined by the International Union of Pure and Applied Chemistry, is "an ensemble of steric
and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target and to trigger (or to block) its biological response.
In the small intestine, the macromolecules cannot permeate through tight junctions of the intestinal cell wall because of multiple factors, including molecular size and steric
hindrance effects, and are vulnerable to further enzymatic and hydrolytic degradation.
The most common fats, available in different mushrooms are steric
, oleic, palmitic, and linoleic acids.
The good ductility and low steric
hindrance of the methyl groups coupled with the chemical inertness of the phenyl groups yields coatings with utmost endurance to aggressive chemicals and, above all, that are suitable as corrosion retardants on sensitive steel substrates.
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This dense structure makes the effect of steric
hindrance act on the Cr (VI) removal.
In some cases, the neutralization of surface charges is only possible by adding a buffer, such as sodium phosphate or molecules with longer uncharged tails, like diaminopimelic acid (electrostatic or steric
stabilization), as illustrated in Figure 1.
hindrance is expected for the [pi] Ru complex with the internal double bond in the grandiflorenic substrate, leading to no hydrogenation of this internal double bond.