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Related to statins: pravastatin, Lipitor

re·leas·ing fac·tors (RF),

1. any substance, usually of hypothalamic origin, capable of accelerating the rate of secretion of a given hormone by the anterior pituitary gland;
2. factors required in the termination phase of either RNA biosynthesis or protein biosynthesis. Synonym(s): termination factor
3. colloquial shortened form for the HMG-CoA reductase inhibitors used as antihyperlipidemic agents, whose generic names end with the suffix statin. Synonym(s): statins


Drugs of the hydroxymethyl glutaryl coenzyme A reductase inhibitor class (HMG-CoA reductase inhibitors). These drugs block the liver's production of cholesterol by competitive inhibition of the reductase coenzyme that catalyzes the rate-limiting step of cholesterol synthesis. They can lower the levels of low-density lipoproteins (LDLs) by 25–45 per cent and a number of major trials have shown their benefits in preventing heart attacks and other effects of ATHEROSCLEROSIS. They reduce the risk of sepsis and fatal sepsis in people with cardiovascular disease, and it has been established that intensive statin treatment after heart attacks provides greater protection against death than does a standard regimen. Recent research on mice has suggested that statins may have some value in MULTIPLE SCLEROSIS because of an effect of diminishing the cellular immune reponse. This growing drug class includes atorvastatin (Lipitor), cerivastatin (Liponay), fluvastatin (Lescol), pravastatin (Lipostat), rosuvastatin (Crestor) and simvastatin (Zocor). Note that the root ‘statin’ has proved popular with pharmacological neologists so, unfortunately, there are many other drugs, not in the HMG-CoA reductase inhibitor class, with ‘statin’ in their names.


A class of drugs commonly used to lower LDL cholesterol levels.
Mentioned in: C-Reactive Protein


blood lipid-regulating drugs, e.g. atorvastatin, simvastatin, indicated as prophylactic therapy in patients with coronary or peripheral vascular disease, and in diabetic and hypertensive patients; 40mg daily reduces atherosclerotic plaque formation

Patient discussion about statins

Q. husband has horrible rash bil. below knees to his ankles. it is bright red yellow weeping cracks. On statins He has been on zocor for 15 years and we are so afraid this may have something to do with this drug. He has stopped taking the drug because the pain and weakness, and numbness in his legs is considerable

A. i looked up for side effects and i saw only "eczema" as a skin side effect. but it seems odd to me that after 15 years you got this kind of side effect. it should have appeared years ago. you know- it might be a very good idea to go and see a Dr... and not stopping a medication without warning..

More discussions about statins
References in periodicals archive ?
In a survey of individuals who have experienced side effects from statins in the past and have stopped taking them, 89% would consider taking statins again if they could potentially reduce the side effects.
With adjustment for age, body mass index, serum albumin, and fibrosis-4 and MELD (Model for End-Stage Liver Disease) scores, the rates of both death and cirrhosis decompensation were each a statistically significant 45% lower among the patients on statins, compared with those not on a statin, they reported.
Ravnskov, "The adverse effects suffered by people taking statins are more common than reported in the media and at medical conferences.
There has been a recent worldwide shift towards recommending treatment with statins to people without existing cardiovascular disease but with a sufficiently high risk of future disease.
The statin and cancer excitement took off with Nielsen's November 2012 study, which reported that people in Denmark who took statins had a lower risk of dying from cancer than non-statin users.
Researchers compared 6,113 statin users and 27,000 non-statin users to assess the incidence of cataracts between the two groups.
The protective effect of statins remained in different age, gender and cardiovascular risk subgroups.
The report also includes insights into the statins R&D product pipeline, and explores the competitive landscape, including major players in the statins market.
Under the Taiwanese health system, doctors have to stop prescribing statins once a patient's cholesterol falls to its target level.
But a recent article in the British Medical Journal stated that the benefits of statins in lowering cholesterol and preventing heart attacks outweigh the potential risk of diabetes.
A total of 2 067 639 patients aged 40 years or older and newly treated with statins between 1 January 1997 and 30 April 2008 participated.