acts more distally than HMGCoA-reductase (the target of statins) in the biosynthesis of cholesterol.
Another non-alkaloidal enzyme, squalene synthase, was also partially purified from a membrane-rich fraction obtained from cell suspension cultures of T.
Squalene synthase from cell suspension cultures of Tabernaemontana divaricata.
Inhibition of cholesterol synthesis by squalene synthase
inhibitors does not induce myotoxicity in vitro.
Aggressive treatment will also boost uptake of novel LDL-lowering therapies such as lapaquistat, Takeda's novel squalene synthase
inhibitor, which will be used in polypharmacy regimens.
Lanosterot 14alpha-demethylase (CYP51), NADPH-cytochrome P450 reductase and squalene synthase
in spermatogenesis: late spermatids of the rat express proteins needed to synthesize follicular fluid meiosis activating sterol.
To thwart this protozoan, researchers have targeted squalene synthase, an enzyme that T.
Urbina of the Venezuelan Institute of Scientific Research in Caracas and his colleagues used the chemical BPQ--for 3-Coiphenyl-4-yl)-quinuclidine--which is known to inhibit squalene synthase.
When its squalene synthase is disabled, Urbina says, "the parasite has no way to compensate.