squalene epoxidase

squa·lene e·pox·i·dase

an enzyme that catalyzes the conversion of squalene to squalene 2,3-oxide in the endoplasmic reticulum; a required step in order for cyclization to occur, resulting in the synthesis of the first sterol, lanosterol, in steroidogenesis; uses NADPH.
Mentioned in ?
References in periodicals archive ?
These authors showed that some gallates are potent inhibitors of the enzyme squalene epoxidase, which is involved in the biosynthesis of ergosterol [42] and, therefore, is essential for the survival of the microorganism.
Inhibition of squalene epoxidase by allylamines results in sterol deficiency in the fungal cell wall and also intracellular accumulation of squalene and finally fungal cell death.
Furthermore, squalene epoxidase, the therapeutic target for numerous antifungal medications, depends on the presence of NADPH or NADH and uses FAD to shuttle electrons from NADPH cytochrome P450 reductase.
Its mode of action is by inhibiting squalene epoxidase which converts squalene to lanosterol.
Squalene epoxidase as hypocholesterolemic drug target revisited.
Certain of these theaflavins have exhibited potent inhibition of the enzyme squalene epoxidase, a key enzyme involved in the body's synthesis of cholesterol.
Cyp1b1 was best predicted by spleen tyrosine kinase (31%), squalene epoxidase (16%), and nicotinamide adenine dinucleotide (NADH) dehydrogenase (Ndufc1) (14%).
Fungicide; inhibits squalene epoxidase, which decreases ergosterol synthesis and causes fungal cell death.
A number of enzymes, including [Beta]-lactamases, carboxypeptidases, and squalene epoxidase, are under current study to develop inhibitors which may be useful medicinal agents and to gain insights into mechanisms of catalysis.
11) Terbinafine inhibits squalene epoxidase, an enzyme involved in the synthesis of ergosterol, which gives terbinafine both fungicidal and fungistatic activity.
mitochondrial CPT1, acyl-CoA thioester hydrolase, 3-hydroxy-3-methylglutamyl-CoA (HMG-CoA) reductase, squalene epoxidase, farnesyl diphosphate (FPP)-transferase, FPP-synthase were upregulated, while acyl-CoA desaturase, acyl-CoA synthetase, and acyl-CoA oxidase 2 were downregulated) (Ratra et al 1998b).