splenomegaly


Also found in: Dictionary, Thesaurus, Legal, Financial, Encyclopedia, Wikipedia.

splenomegaly

 [sple″no-meg´ah-le]
enlargement of the spleen.
congestive splenomegaly splenomegaly secondary to portal hypertension, with ascites, anemia, thrombocytopenia, leukopenia, and episodic hemorrhage from the intestinal tract. Called also Banti's disease.
hemolytic splenomegaly enlargement of the spleen associated with hemolytic diseases of the blood.
siderotic splenomegaly splenomegaly with deposit of iron and calcium.

sple·no·meg·a·ly

, splenomegalia (splē'nō-meg'ă-lē, -mĕ-gā'lē-ă),
Enlargement of the spleen.
Synonym(s): megalosplenia
[spleno- + G. megas (megal-), large]

splenomegaly

/sple·no·meg·a·ly/ (-meg´ah-le) enlargement of the spleen.
congestive splenomegaly  Banti's disease; splenomegaly secondary to portal hypertension.
hemolytic splenomegaly  that associated with any disorder causing increased erythrocyte degradation.

splenomegaly

(splē′nō-mĕg′ə-lē, splĕn′ō-)
n. pl. splenomega·lies
Enlargement of the spleen.

splenomegaly

[splē′nōmeg′əlē, splen′-]
Etymology: Gk, splen + megas, large
an abnormal enlargement of the spleen, as is associated with portal hypertension, hemolytic anemia, Niemann-Pick disease, or malaria.
enlarge picture
Splenomegaly

splenomegaly

Enlarged spleen Enlargement of spleen for any reason, which is usually a manifestation of underlying disease; the only specific finding in splenomegaly is dragging sensation in the upper right quadrant; megalic spleens may reach 4.0+ kg–eg, in agnogenic myeloid metaplasia
Splenomegaly
Congestion Cirrhosis, CHF, thrombosis of portal or splenic veins
Infection
• Bacteria Brucellosis, infective carditis agents, syphilis, TB, typhoid fever
• Fungi Histoplasmosis
• Parasites Echinococcosis, leishmaniasis, malaria, schistosomiasis, toxoplasmosis, trypanosomiasis
• Viruses CMV, EBV
Inflammatory/immune-related Rheumatoid arthritis, SLE
Hematopoietic disease/Lymphoid function
• Malignant Leukemias, eg ALL, CLL, myeloproliferative disorders–eg agnogenic myeloid metaplasia, CML, multiple myeloma, polycythemia vera; lymphomas–Hodgkin's disease, NHL
• Nonmalignant Hemolytic anemia, histiocytosis, ITP
Storage diseases Gaucher's disease, mucopolysaccharidosis, Niemann-Pick disease
Etc Amyloidosis, cysts, hypersplenism, metastases, primary tumors

sple·no·meg·a·ly

, splenomegalia (splēnō-megă-lē, -mĕ-gālē-ă)
Enlargement of the spleen.
Synonym(s): megalosplenia.
[spleno- + G. megas (megal-), large]

splenomegaly

SPLEEN ENLARGEMENT.

Splenomegaly

Abnormal enlargement of the spleen. Splenomegaly is a major diagnostic criterion of PV.

splenomegaly (spleˈ·nō·meˑ·g·lē),

n an abnormal increase in the size of the spleen; often associated with hemolytic anemia, mononucleosis, leukemia, portal hypertension, or malaria.
Enlarge picture
Splenomegaly.

sple·no·meg·a·ly

, splenomegalia (splēnō-megă-lē, -mĕ-gālē-ă)
Enlargement of the spleen.
[spleno- + G. megas (megal-), large]

splenomegaly (splē´nōmeg´əlē),

n an abnormal enlargement of the spleen, usually associated with portal hypertension, hemolytic anemia, and malaria.

splenomegaly

enlargement of the spleen. Is largely without clinical signs but it may be palpated during an examination through the abdominal wall in dogs and cats, rectally in horses and not at all in ruminants. The enlargements may be caused by abscess or neoplasm or there may be a diffuse enlargement caused by accumulation of hemolyzed red cells.

asymmetrical splenomegaly
usually the result of trauma or neoplasia.
congestive splenomegaly
in animals, most often caused by splenic torsion.
hemolytic splenomegaly
that associated with hemolytic anemia.
siderotic splenomegaly
splenomegaly with deposit of iron and calcium.
symmetrical splenomegaly
usually caused by congestion or infiltration of the splenic tissue.
References in periodicals archive ?
So it is recommended that splenic index would be a better diagnostic tool to measure splenomegaly in patients of esophageal varices secondary to cirrhosis16.
of Patients Percentage Fever 100 100 Headache 60 60 Vomiting 60 60 Abnormal behaviour 33 33 Convulsion 36 36 Unconsciousness 28 28 Diminished urine output 24 24 Dark coloured urine 18 18 Anaemia 42 42 Jaundice 46 46 Pulmonary oedema/ ARDS 3 3 Hepatomegaly 48 48 Splenomegaly 86 86 Table 5.
In this patient, the splenomegaly, engorged SGVs, and CORs noted on CT [Figure 1] could have resulted from the splenic vein obstruction by the neoplasm at the pancreatic tail.
It is believed that patients with HMS have a hyper production of polyclonal IgM, (1) which is linked to suppressor T lymphocytes (cytotoxic phenotype), causing the elimination of the parasite, as well as generating immune complexes that are deposited in the spleen, thus resulting in splenomegaly.
Released from damaged hepatocytes Ferritin receptor down-regulation Hypertriglyceridaemia Liver infiltration by histiocytes Decreased levels of lipoprotein lipase Hypofibrinogenaemia Liver infiltration Hepatomegaly/ Organ infiltration by activated histiocytes splenomegaly Cutaneous Histiocytic and lymphocytic infiltration manifestations (commonly panniculitis and/ or purpura) Pathology Differential diagnosis Cytopenia/s Bone marrow hypoplasia/ failure Bone marrow infiltration (malignant, infective) Drug-induced myelotoxicity (e.
The nuclear medicine liver spleen scan with Tc-99m sulfur colloid was useful to show splenomegaly and colloid shift with an increased spleen to liver ratio suggestive of hypersplenism (Figure 3).
His splenomegaly had decreased to 15 cm, and his hemoglobin was stable at 11.
12) In an effort to better delineate the frequency of splenomegaly in noncirrhotic patients with steatosis and NASH, we arbitrarily chose 2 higher cutoff thresholds for spleen weight in both men and women (230 g and 250 g for women and men, respectively, and also 280 g and 300 g, respectively).
After the injections period, five groups of mice (n=10 mice/ group), were investigated for antimalarial efficacy, degree of parasitaemia, assessment of pathology including body weight, physiological activities, hepatomegaly, splenomegaly and anemia.
Splenomegaly would be especially significant in this case as it would be highly suggestive of myelofibrosis in combination with tear drop cells wit pancytopenia in an elderly patient (3).
On physical exam, we noted splenomegaly (spleen was approximately 3 cm below costal margin); all other exam findings were within normal limits.